{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pihlajamaki J"],"funding":["NIDDK NIH HHS","NCRR NIH HHS","PHS HHS","NIGMS NIH HHS"],"pagination":["208-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3167228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Alternative mRNA splicing provides transcript diversity and may contribute to human disease. We demonstrate that expression of several genes regulating RNA processing is decreased in both liver and skeletal muscle of obese humans. We evaluated a representative splicing factor, SFRS10, downregulated in both obese human liver and muscle and in high-fat-fed mice, and determined metabolic impact of reduced expression. SFRS10-specific siRNA induces lipogenesis and lipid accumulation in hepatocytes. Moreover, Sfrs10 heterozygous mice have increased hepatic lipogenic gene expression, VLDL secretion, and plasma triglycerides. We demonstrate that LPIN1, a key regulator of lipid metabolism, is a splicing target of SFRS10; reduced SFRS10 favors the lipogenic β isoform of LPIN1. Importantly, LPIN1β-sp"],"journal":["Cell metabolism"],"pubmed_title":["Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis."],"pmcid":["PMC3167228"],"funding_grant_id":["M01 RR001032","DK060837","S10 RR024598","R01 DK062948","DK062948","D36836","R01 DK060837","R01GM50388","R01 DK070648","P20RR021964","R01 GM083187","P30 DK036836","R01 GM050388","DK70648"],"pubmed_authors":["Park PJ","Crunkhorn S","Boes T","Miettinen P","Lerin C","Floss T","Zhao Z","Wurst W","Kuulasmaa T","Nasser I","Ren H","Stamm S","Pihlajamaki J","Zhang Z","Itkonen P","Schroeder J","Dearie F","Burak F","Goldfine AB","Jimenez-Chillaron JC","Laakso M","Morris AJ","Xu Y","Patti ME"],"additional_accession":[]},"is_claimable":false,"name":"Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.","description":"Alternative mRNA splicing provides transcript diversity and may contribute to human disease. We demonstrate that expression of several genes regulating RNA processing is decreased in both liver and skeletal muscle of obese humans. We evaluated a representative splicing factor, SFRS10, downregulated in both obese human liver and muscle and in high-fat-fed mice, and determined metabolic impact of reduced expression. SFRS10-specific siRNA induces lipogenesis and lipid accumulation in hepatocytes. Moreover, Sfrs10 heterozygous mice have increased hepatic lipogenic gene expression, VLDL secretion, and plasma triglycerides. We demonstrate that LPIN1, a key regulator of lipid metabolism, is a splicing target of SFRS10; reduced SFRS10 favors the lipogenic β isoform of LPIN1. Importantly, LPIN1β-sp","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2026-05-01T02:17:01.534Z","creation":"2026-04-07T16:33:50.55Z"},"accession":"S-EPMC3167228","cross_references":{"pubmed":["21803291"],"doi":["10.1016/j.cmet.2011.06.007"]}}