{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Swanson WJ"],"funding":["NICHD NIH HHS","European Research Council","European Commission FP7"],"pagination":["1963-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3167683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["Species-specific recognition between egg and sperm, a crucial event that marks the beginning of fertilization in multicellular organisms, mirrors the binding between haploid cells of opposite mating type in unicellular eukaryotes such as yeast. However, as implied by the lack of sequence similarity between sperm-binding regions of invertebrate and vertebrate egg coat proteins, these interactions are thought to rely on completely different molecular entities. Here, we argue that these recognition systems are, in fact, related: despite being separated by 0.6-1 billion years of evolution, functionally essential domains of a mollusc sperm receptor and a yeast mating protein adopt the same 3D fold as egg zona pellucida proteins mediating the binding between gametes in humans."],"journal":["Molecular biology and evolution"],"pubmed_title":["The molecular basis of sex: linking yeast to human."],"pmcid":["PMC3167683"],"funding_grant_id":["R01 HD042563","R01 HD057974","R37 HD012986","HD042563","HD057974","HD 054631","FP7_260759","R03 HD054631","HD12986","260759"],"pubmed_authors":["Aagaard JE","Swanson WJ","Vacquier VD","Jovine L","Monne M","Sadat Al Hosseini H"],"additional_accession":[]},"is_claimable":false,"name":"The molecular basis of sex: linking yeast to human.","description":"Species-specific recognition between egg and sperm, a crucial event that marks the beginning of fertilization in multicellular organisms, mirrors the binding between haploid cells of opposite mating type in unicellular eukaryotes such as yeast. However, as implied by the lack of sequence similarity between sperm-binding regions of invertebrate and vertebrate egg coat proteins, these interactions are thought to rely on completely different molecular entities. Here, we argue that these recognition systems are, in fact, related: despite being separated by 0.6-1 billion years of evolution, functionally essential domains of a mollusc sperm receptor and a yeast mating protein adopt the same 3D fold as egg zona pellucida proteins mediating the binding between gametes in humans.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jul","modification":"2025-04-04T07:25:25.866Z","creation":"2019-03-27T00:43:40Z"},"accession":"S-EPMC3167683","cross_references":{"pubmed":["21282709"],"doi":["10.1093/molbev/msr026"]}}