{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":62,"searchCount":0},"additional":{"submitter":["Sieburth DS"],"funding":["NIGMS NIH HHS"],"pagination":["2562-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC317062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(19)"],"pubmed_abstract":["We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A-B mutations suppress the Multivulva phenotype of an activated ras mutation and enhance the Vulvaless phenotype of mutations in lin-45 raf, sur-8, or mpk-1. Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling."],"journal":["Genes & development"],"pubmed_title":["A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction."],"pmcid":["PMC317062"],"funding_grant_id":["GM47869","R01 GM047869"],"pubmed_authors":["Sundaram M","Han M","Sieburth DS","Howard RM"],"view_count":["62"],"additional_accession":[]},"is_claimable":false,"name":"A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.","description":"We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A-B mutations suppress the Multivulva phenotype of an activated ras mutation and enhance the Vulvaless phenotype of mutations in lin-45 raf, sur-8, or mpk-1. Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling.","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 Oct","modification":"2024-11-06T08:25:36.408Z","creation":"2019-03-27T00:49:59Z"},"accession":"S-EPMC317062","cross_references":{"pubmed":["10521400"],"doi":["10.1101/gad.13.19.2562"]}}