{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lane SW"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["2849-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3172801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(10)"],"pubmed_abstract":["Hematopoietic stem cells (HSCs) engage in complex bidirectional signals with the hematopoietic microenvironment (HM), and there is emerging evidence that leukemia stem cells (LSCs) may use similar interactions. Using a syngeneic retroviral model of MLL-AF9 induced acute myeloid leukemia (AML), we have identified 2 different stages of leukemia progression, propagated by \"pre-LSCs\" and established leukemia (LSCs) and compared the homing properties of these distinctive entities to that of normal HSCs. The homing and microlocalization of pre-LSCs was most similar to long-term HSCs and was dependent on cell-intrinsic Wnt signaling. In contrast, the homing of established LSCs was most similar to that of committed myeloid progenitors and distinct from HSCs. Although osteoblast-derived Dickkopf-1,"],"journal":["Blood"],"pubmed_title":["Differential niche and Wnt requirements during acute myeloid leukemia progression."],"pmcid":["PMC3172801"],"funding_grant_id":["R01 DK062757","P01 CA066996","R01 HL044851","DK62757","HL44851","CA66996"],"pubmed_authors":["Lane SW","Sykes SM","Bullinger L","Ferraro F","Lo Celso C","Wang YJ","Armstrong SA","Williams DA","Ragu C","Shterental S","Lin CP","Scadden DT","Gilliland DG"],"additional_accession":[]},"is_claimable":false,"name":"Differential niche and Wnt requirements during acute myeloid leukemia progression.","description":"Hematopoietic stem cells (HSCs) engage in complex bidirectional signals with the hematopoietic microenvironment (HM), and there is emerging evidence that leukemia stem cells (LSCs) may use similar interactions. Using a syngeneic retroviral model of MLL-AF9 induced acute myeloid leukemia (AML), we have identified 2 different stages of leukemia progression, propagated by \"pre-LSCs\" and established leukemia (LSCs) and compared the homing properties of these distinctive entities to that of normal HSCs. The homing and microlocalization of pre-LSCs was most similar to long-term HSCs and was dependent on cell-intrinsic Wnt signaling. In contrast, the homing of established LSCs was most similar to that of committed myeloid progenitors and distinct from HSCs. Although osteoblast-derived Dickkopf-1,","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2025-07-02T03:04:57.89Z","creation":"2025-07-02T03:04:57.89Z"},"accession":"S-EPMC3172801","cross_references":{"pubmed":["21765021"],"doi":["10.1182/blood-2011-03-345165"]}}