{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lovewell RR"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["e1002253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3174259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["Phagocytosis of bacteria by innate immune cells is a primary method of bacterial clearance during infection. However, the mechanisms by which the host cell recognizes bacteria and consequentially initiates phagocytosis are largely unclear. Previous studies of the bacterium Pseudomonas aeruginosa have indicated that bacterial flagella and flagellar motility play an important role in colonization of the host and, importantly, that loss of flagellar motility enables phagocytic evasion. Here we use molecular, cellular, and genetic methods to provide the first formal evidence that phagocytic cells recognize bacterial motility rather than flagella and initiate phagocytosis in response to this motility. We demonstrate that deletion of genes coding for the flagellar stator complex, which results i"],"journal":["PLoS pathogens"],"pubmed_title":["Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion."],"pmcid":["PMC3174259"],"funding_grant_id":["P30 CA023108","R01 AI083256","GM008704","T32 GM008704","R01 AI067405"],"pubmed_authors":["Lovewell RR","O'Toole GA","Acker JL","Wargo MJ","Berwin B","Collins RM"],"additional_accession":[]},"is_claimable":false,"name":"Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion.","description":"Phagocytosis of bacteria by innate immune cells is a primary method of bacterial clearance during infection. However, the mechanisms by which the host cell recognizes bacteria and consequentially initiates phagocytosis are largely unclear. Previous studies of the bacterium Pseudomonas aeruginosa have indicated that bacterial flagella and flagellar motility play an important role in colonization of the host and, importantly, that loss of flagellar motility enables phagocytic evasion. Here we use molecular, cellular, and genetic methods to provide the first formal evidence that phagocytic cells recognize bacterial motility rather than flagella and initiate phagocytosis in response to this motility. We demonstrate that deletion of genes coding for the flagellar stator complex, which results i","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2025-05-29T22:12:15.069Z","creation":"2025-05-29T22:12:15.069Z"},"accession":"S-EPMC3174259","cross_references":{"pubmed":["21949654"],"doi":["10.1371/journal.ppat.1002253"]}}