{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ames HM"],"funding":["NCI NIH HHS"],"pagination":["2113-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3174286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["131(10)"],"pubmed_abstract":["Merkel cell carcinoma (MCC) is a neoplasm thought to originate from the neuroendocrine Merkel cells of the skin. Although the prevalence of MCC has been increasing, treatments for this disease remain limited because of a paucity of information regarding MCC biology. We have found that the endocytic oncoprotein Huntingtin-interacting protein 1 (HIP1) is expressed at high levels in ∼90% of MCC tumors and serves as a more reliable histological cytoplasmic stain than the gold standard, cytokeratin 20. Furthermore, high anti-HIP1 antibody reactivity in the sera of a cohort of MCC patients predicts the presence of metastases. Another protein that is frequently expressed at high levels in MCC tumors is the stem cell factor (SCF) receptor tyrosine kinase, c-Kit. In working toward an understanding of how HIP1 might contribute to MCC tumorigenesis, we have discovered that HIP1 interacts with SCF-activated c-Kit. These data not only identify HIP1 as a molecular marker for management of MCC patients but also show that HIP1 interacts with and slows the degradation of c-Kit."],"journal":["The Journal of investigative dermatology"],"pubmed_title":["Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit."],"pmcid":["PMC3174286"],"funding_grant_id":["P30 CA046592","R01 CA098730-01","R01 CA082363-01A1","R01 CA087837","R01 CA82363-03","R01 CA098730-05A1","R01 CA098730","R01 CA082363"],"pubmed_authors":["Ross TS","Ames HM","Bichakjian CK","Verhaegen ME","Dlugosz AA","Liu GY","Fullen DR","Johnson TM","Oravecz-Wilson KI"],"additional_accession":[]},"is_claimable":false,"name":"Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.","description":"Merkel cell carcinoma (MCC) is a neoplasm thought to originate from the neuroendocrine Merkel cells of the skin. Although the prevalence of MCC has been increasing, treatments for this disease remain limited because of a paucity of information regarding MCC biology. We have found that the endocytic oncoprotein Huntingtin-interacting protein 1 (HIP1) is expressed at high levels in ∼90% of MCC tumors and serves as a more reliable histological cytoplasmic stain than the gold standard, cytokeratin 20. Furthermore, high anti-HIP1 antibody reactivity in the sera of a cohort of MCC patients predicts the presence of metastases. Another protein that is frequently expressed at high levels in MCC tumors is the stem cell factor (SCF) receptor tyrosine kinase, c-Kit. In working toward an understanding of how HIP1 might contribute to MCC tumorigenesis, we have discovered that HIP1 interacts with SCF-activated c-Kit. These data not only identify HIP1 as a molecular marker for management of MCC patients but also show that HIP1 interacts with and slows the degradation of c-Kit.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2024-11-09T09:49:53.119Z","creation":"2019-03-27T00:44:00Z"},"accession":"S-EPMC3174286","cross_references":{"pubmed":["21697888"],"doi":["10.1038/jid.2011.171"]}}