{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu H"],"funding":["NEI NIH HHS","NIDA NIH HHS","NIAAA NIH HHS"],"pagination":["4132-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3175941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(7)"],"pubmed_abstract":["<h4>Purpose</h4>To use a systematic genetics approach to investigate the regulation of Gpnmb, a gene that contributes to pigmentary dispersion syndrome (PDS) and pigmentary glaucoma (PG) in the DBA/2J (D2) mouse.<h4>Methods</h4>Global patterns of gene expression were studied in whole eyes of a large family of BXD mouse strains (n = 67) generated by crossing the PDS- and PG-prone parent (DBA/2J) with a resistant strain (C57BL/6J). Quantitative trait locus (eQTL) mapping methods and gene set analysis were used to evaluate Gpnmb coexpression networks in wild-type and mutant cohorts.<h4>Results</h4>The level of Gpnmb expression was associated with a highly significant cis-eQTL at the location of the gene itself. This autocontrol of Gpnmb is likely to be a direct consequence of the known premat"],"journal":["Investigative ophthalmology & visual science"],"pubmed_title":["Genetic dissection of the Gpnmb network in the eye."],"pmcid":["PMC3175941"],"funding_grant_id":["AA017590","U01 AA014425","EY017841","R01 EY021200","P30 EY013080","P20 DA021131","R01 EY017841-04","P30EY013080","EY021200","AA014425","U01 AA017590","R01 EY017841","DA021131"],"pubmed_authors":["Lu L","Jablonski MM","Sahu S","Lu H","Guan H","Pullen M","Williams RW","Geisert EE","Wang X","Chen H","Zhang B"],"additional_accession":[]},"is_claimable":false,"name":"Genetic dissection of the Gpnmb network in the eye.","description":"<h4>Purpose</h4>To use a systematic genetics approach to investigate the regulation of Gpnmb, a gene that contributes to pigmentary dispersion syndrome (PDS) and pigmentary glaucoma (PG) in the DBA/2J (D2) mouse.<h4>Methods</h4>Global patterns of gene expression were studied in whole eyes of a large family of BXD mouse strains (n = 67) generated by crossing the PDS- and PG-prone parent (DBA/2J) with a resistant strain (C57BL/6J). Quantitative trait locus (eQTL) mapping methods and gene set analysis were used to evaluate Gpnmb coexpression networks in wild-type and mutant cohorts.<h4>Results</h4>The level of Gpnmb expression was associated with a highly significant cis-eQTL at the location of the gene itself. This autocontrol of Gpnmb is likely to be a direct consequence of the known premat","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-05T09:13:57.456Z","creation":"2019-03-27T00:44:05Z"},"accession":"S-EPMC3175941","cross_references":{"pubmed":["21398278"],"doi":["10.1167/iovs.10-6493"]}}