biostudies-literatureLu HNEI NIH HHSNIDA NIH HHSNIAAA NIH HHS4132-42https://www.ebi.ac.uk/biostudies/studies/S-EPMC3175941biostudies-literatureUnknown52(7)<h4>Purpose</h4>To use a systematic genetics approach to investigate the regulation of Gpnmb, a gene that contributes to pigmentary dispersion syndrome (PDS) and pigmentary glaucoma (PG) in the DBA/2J (D2) mouse.<h4>Methods</h4>Global patterns of gene expression were studied in whole eyes of a large family of BXD mouse strains (n = 67) generated by crossing the PDS- and PG-prone parent (DBA/2J) with a resistant strain (C57BL/6J). Quantitative trait locus (eQTL) mapping methods and gene set analysis were used to evaluate Gpnmb coexpression networks in wild-type and mutant cohorts.<h4>Results</h4>The level of Gpnmb expression was associated with a highly significant cis-eQTL at the location of the gene itself. This autocontrol of Gpnmb is likely to be a direct consequence of the known prematInvestigative ophthalmology & visual scienceGenetic dissection of the Gpnmb network in the eye.PMC3175941AA017590U01 AA014425EY017841R01 EY021200P30 EY013080P20 DA021131R01 EY017841-04P30EY013080EY021200AA014425U01 AA017590R01 EY017841DA021131Lu LJablonski MMSahu SLu HGuan HPullen MWilliams RWGeisert EEWang XChen HZhang BfalseGenetic dissection of the Gpnmb network in the eye.<h4>Purpose</h4>To use a systematic genetics approach to investigate the regulation of Gpnmb, a gene that contributes to pigmentary dispersion syndrome (PDS) and pigmentary glaucoma (PG) in the DBA/2J (D2) mouse.<h4>Methods</h4>Global patterns of gene expression were studied in whole eyes of a large family of BXD mouse strains (n = 67) generated by crossing the PDS- and PG-prone parent (DBA/2J) with a resistant strain (C57BL/6J). Quantitative trait locus (eQTL) mapping methods and gene set analysis were used to evaluate Gpnmb coexpression networks in wild-type and mutant cohorts.<h4>Results</h4>The level of Gpnmb expression was associated with a highly significant cis-eQTL at the location of the gene itself. This autocontrol of Gpnmb is likely to be a direct consequence of the known premat2011-01-01T00:00:00Z2011 Jun2025-04-05T09:13:57.456Z2019-03-27T00:44:05ZS-EPMC31759412139827810.1167/iovs.10-6493