{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Aksaas AK"],"pubmed_abstract":["Background
Post-transcriptional processing of pre-mRNA takes place in several steps and requires involvement of a number of RNA-binding proteins. How pre-mRNA processing is regulated is in large enigmatic. The catalytic (C) subunit of protein kinase A (PKA) is a serine/threonine kinase, which regulates numerous cellular processes including pre-mRNA splicing. Despite that a significant fraction of the C subunit is found in splicing factor compartments in the nucleus, there are no indications of a direct interaction between RNA and PKA. Based on this we speculate if the specificity of the C subunit in regulating pre-mRNA splicing may be mediated indirectly through other nuclear proteins.Results
Using yeast two-hybrid screening with the PKA C subunit Cbeta2 as bait, we identif"],"journal":["Journal of molecular signaling"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3179746"],"repository":["biostudies-literature"],"pubmed_title":["G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A."],"pmcid":["PMC3179746"],"pubmed_authors":["Kvissel AK","Skalhegg BS","Rogne M","Rosendal K","Larsen AC","Aksaas AK"],"additional_accession":[]},"is_claimable":false,"name":"G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.","description":"Background
Post-transcriptional processing of pre-mRNA takes place in several steps and requires involvement of a number of RNA-binding proteins. How pre-mRNA processing is regulated is in large enigmatic. The catalytic (C) subunit of protein kinase A (PKA) is a serine/threonine kinase, which regulates numerous cellular processes including pre-mRNA splicing. Despite that a significant fraction of the C subunit is found in splicing factor compartments in the nucleus, there are no indications of a direct interaction between RNA and PKA. Based on this we speculate if the specificity of the C subunit in regulating pre-mRNA splicing may be mediated indirectly through other nuclear proteins.Results
Using yeast two-hybrid screening with the PKA C subunit Cbeta2 as bait, we identif","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Aug","modification":"2026-04-07T14:10:43.251Z","creation":"2025-07-09T03:05:16.281Z"},"accession":"S-EPMC3179746","cross_references":{"pubmed":["21880142"],"doi":["10.1186/1750-2187-6-10"]}}