{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dowal L"],"funding":["NHLBI NIH HHS"],"pagination":["e62-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3186346"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(13)"],"pubmed_abstract":["Protein palmitoylation is a dynamic process that regulates membrane targeting of proteins and protein-protein interactions. We have previously demonstrated a critical role for protein palmitoylation in platelet activation and have identified palmitoylation machinery in platelets. Using a novel proteomic approach, Palmitoyl Protein Identification and Site Characterization, we have begun to characterize the human platelet palmitoylome. Palmitoylated proteins were enriched from membranes isolated from resting platelets using acyl-biotinyl exchange chemistry, followed by identification using liquid chromatography-tandem mass spectrometry. This global analysis identified > 1300 proteins, of which 215 met criteria for significance and represent the platelet palmitoylome. This collection includes"],"journal":["Blood"],"pubmed_title":["Proteomic analysis of palmitoylated platelet proteins."],"pmcid":["PMC3186346"],"funding_grant_id":["T32 HL07917","T32 HL007917","HL87203","P01 HL087203"],"pubmed_authors":["Yang W","Flaumenhaft R","Freeman MR","Steen H","Dowal L"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic analysis of palmitoylated platelet proteins.","description":"Protein palmitoylation is a dynamic process that regulates membrane targeting of proteins and protein-protein interactions. We have previously demonstrated a critical role for protein palmitoylation in platelet activation and have identified palmitoylation machinery in platelets. Using a novel proteomic approach, Palmitoyl Protein Identification and Site Characterization, we have begun to characterize the human platelet palmitoylome. Palmitoylated proteins were enriched from membranes isolated from resting platelets using acyl-biotinyl exchange chemistry, followed by identification using liquid chromatography-tandem mass spectrometry. This global analysis identified > 1300 proteins, of which 215 met criteria for significance and represent the platelet palmitoylome. This collection includes","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2026-06-03T10:52:10.485Z","creation":"2026-04-28T03:11:04.814Z"},"accession":"S-EPMC3186346","cross_references":{"pubmed":["21813449"],"doi":["10.1182/blood-2011-05-353078"]}}