{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alushin G"],"funding":["Howard Hughes Medical Institute","NIGMS NIH HHS"],"pagination":["661-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3189262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(5)"],"pubmed_abstract":["Kinetochores are large macromolecular assemblies that link chromosomes to spindle microtubules (MTs) during mitosis. Here we review recent advances in the study of core MT-binding kinetochore complexes using electron microcopy methods in vitro and nanometer-accuracy fluorescence microscopy in vivo. We synthesize these findings in novel three-dimensional models of both the budding yeast and vertebrate kinetochore in different stages of mitosis. There is a growing consensus that kinetochores are highly dynamic, supra-molecular machines that undergo dramatic structural rearrangements in response to MT capture and spindle forces during mitosis."],"journal":["Current opinion in structural biology"],"pubmed_title":["Visualizing kinetochore architecture."],"pmcid":["PMC3189262"],"funding_grant_id":["P01 GM051487","P01 GM051487-17"],"pubmed_authors":["Nogales E","Alushin G"],"additional_accession":[]},"is_claimable":false,"name":"Visualizing kinetochore architecture.","description":"Kinetochores are large macromolecular assemblies that link chromosomes to spindle microtubules (MTs) during mitosis. Here we review recent advances in the study of core MT-binding kinetochore complexes using electron microcopy methods in vitro and nanometer-accuracy fluorescence microscopy in vivo. We synthesize these findings in novel three-dimensional models of both the budding yeast and vertebrate kinetochore in different stages of mitosis. There is a growing consensus that kinetochores are highly dynamic, supra-molecular machines that undergo dramatic structural rearrangements in response to MT capture and spindle forces during mitosis.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2024-11-21T00:12:56.961Z","creation":"2019-06-05T16:47:48Z"},"accession":"S-EPMC3189262","cross_references":{"pubmed":["21862320"],"doi":["10.1016/j.sbi.2011.07.009"]}}