{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Loutet SA"],"funding":["Canadian Institutes of Health Research"],"pubmed_abstract":["<h4>Background</h4>Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in three isogenic B. cenocepacia strains with diverse polymyxin B resistance phenotypes: the polymyxin B-resistant parental strain K56-2, a polymyxin B-sensitive K56-2 mutant strain with heptoseless lipopolysaccharide (LPS) (RSF34), and a derivative of RSF34 (RSF34 4000B) isolated through multiple rounds of selection in polymyxin B that despite having a heptoseless LPS is highly polymyxin B-resistant.<h4>Results</h4>A heptoseless LPS mutant of B. cenocepacia was passaged through multiple rounds of selection to regain high levels of polymy"],"journal":["BMC genomics"],"pagination":["472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3190405"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes."],"pmcid":["PMC3190405"],"pubmed_authors":["Molinaro A","Valvano MA","Clarke C","Di Lorenzo F","Loutet SA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes.","description":"<h4>Background</h4>Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in three isogenic B. cenocepacia strains with diverse polymyxin B resistance phenotypes: the polymyxin B-resistant parental strain K56-2, a polymyxin B-sensitive K56-2 mutant strain with heptoseless lipopolysaccharide (LPS) (RSF34), and a derivative of RSF34 (RSF34 4000B) isolated through multiple rounds of selection in polymyxin B that despite having a heptoseless LPS is highly polymyxin B-resistant.<h4>Results</h4>A heptoseless LPS mutant of B. cenocepacia was passaged through multiple rounds of selection to regain high levels of polymy","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2026-04-07T17:30:21.973Z","creation":"2019-03-27T00:44:48Z"},"accession":"S-EPMC3190405","cross_references":{"pubmed":["21955326"],"doi":["10.1186/1471-2164-12-472"]}}