{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Oliveira CA"],"funding":["NCRR NIH HHS","Howard Hughes Medical Institute","NIGMS NIH HHS"],"pagination":["e1002178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3192803"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11-18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline racemase enzyme (TcPR) as an attractive candidate for improved chemotherapeutic intervention. Conformational changes associated with substrate binding to TcPR are believed to expose critical residues that elicit a host mitogenic B-cell response, a process contributing to parasite persistence and immune system evasion. Characterization of the conformational states of TcPR requires access to long-time-scale motions that are currently inaccessible by standard molecular dynamics simulations. Here we descri"],"journal":["PLoS computational biology"],"pubmed_title":["Large-scale conformational changes of Trypanosoma cruzi proline racemase predicted by accelerated molecular dynamics simulation."],"pmcid":["PMC3192803"],"funding_grant_id":["R01 GM031749","P41 RR08605","P41 RR008605","GM31749"],"pubmed_authors":["Zhou M","McCammon JA","de Oliveira CA","Grant BJ"],"additional_accession":[]},"is_claimable":false,"name":"Large-scale conformational changes of Trypanosoma cruzi proline racemase predicted by accelerated molecular dynamics simulation.","description":"Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life-threatening illness affecting 11-18 million people. Currently available treatments are limited, with unacceptable efficacy and safety profiles. Recent studies have revealed an essential T. cruzi proline racemase enzyme (TcPR) as an attractive candidate for improved chemotherapeutic intervention. Conformational changes associated with substrate binding to TcPR are believed to expose critical residues that elicit a host mitogenic B-cell response, a process contributing to parasite persistence and immune system evasion. Characterization of the conformational states of TcPR requires access to long-time-scale motions that are currently inaccessible by standard molecular dynamics simulations. Here we descri","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2026-04-07T23:44:44.513Z","creation":"2026-04-07T19:14:31.102Z"},"accession":"S-EPMC3192803","cross_references":{"pubmed":["22022240"],"doi":["10.1371/journal.pcbi.1002178"]}}