{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(10)"],"submitter":["Meng Q"],"pubmed_abstract":["<h4>Background</h4>Behcet's disease is a chronic, multi-systemic autoimmune disease. Programmed cell death 1 (PD-1) gene is one of non-human leucocyte antigen genes. It has been demonstrated to be associated with several autoimmune diseases. However, only a few studies have addressed the association of ligand genes of PD-1, PD-L1 and PD-L2 with autoimmune disease. The purpose of this study was to analyze the potential association of the PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.<h4>Methodology/principal findings</h4>Four single-nucleotide polymorphism (SNPs) rs2227981 and rs10204525 of PD-1, rs1970000 of PD-L1 and rs7854303 of PD-L2 were genotyped in 405 Behcet's patients and 414 age-, sex-, ethnic-matched healthy controls using polymerase chain reaction-r"],"journal":["PloS one"],"pagination":["e25345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3198443"],"repository":["biostudies-literature"],"pubmed_title":["Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population."],"pmcid":["PMC3198443"],"pubmed_authors":["Jiang Z","Meng Q","Guo H","Yang P","Kijlstra A","Hou S"],"additional_accession":[]},"is_claimable":false,"name":"Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.","description":"<h4>Background</h4>Behcet's disease is a chronic, multi-systemic autoimmune disease. Programmed cell death 1 (PD-1) gene is one of non-human leucocyte antigen genes. It has been demonstrated to be associated with several autoimmune diseases. However, only a few studies have addressed the association of ligand genes of PD-1, PD-L1 and PD-L2 with autoimmune disease. The purpose of this study was to analyze the potential association of the PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.<h4>Methodology/principal findings</h4>Four single-nucleotide polymorphism (SNPs) rs2227981 and rs10204525 of PD-1, rs1970000 of PD-L1 and rs7854303 of PD-L2 were genotyped in 405 Behcet's patients and 414 age-, sex-, ethnic-matched healthy controls using polymerase chain reaction-r","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-04-26T06:18:18.987Z","creation":"2019-03-26T23:16:22Z"},"accession":"S-EPMC3198443","cross_references":{"pubmed":["22039410"],"doi":["10.1371/journal.pone.0025345"]}}