biostudies-literatureUnknown6(10)Meng Q<h4>Background</h4>Behcet's disease is a chronic, multi-systemic autoimmune disease. Programmed cell death 1 (PD-1) gene is one of non-human leucocyte antigen genes. It has been demonstrated to be associated with several autoimmune diseases. However, only a few studies have addressed the association of ligand genes of PD-1, PD-L1 and PD-L2 with autoimmune disease. The purpose of this study was to analyze the potential association of the PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.<h4>Methodology/principal findings</h4>Four single-nucleotide polymorphism (SNPs) rs2227981 and rs10204525 of PD-1, rs1970000 of PD-L1 and rs7854303 of PD-L2 were genotyped in 405 Behcet's patients and 414 age-, sex-, ethnic-matched healthy controls using polymerase chain reaction-rPloS onee25345https://www.ebi.ac.uk/biostudies/studies/S-EPMC3198443biostudies-literatureLack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.PMC3198443Jiang ZMeng QGuo HYang PKijlstra AHou SfalseLack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.<h4>Background</h4>Behcet's disease is a chronic, multi-systemic autoimmune disease. Programmed cell death 1 (PD-1) gene is one of non-human leucocyte antigen genes. It has been demonstrated to be associated with several autoimmune diseases. However, only a few studies have addressed the association of ligand genes of PD-1, PD-L1 and PD-L2 with autoimmune disease. The purpose of this study was to analyze the potential association of the PD-1 and its ligand genes with Behcet's disease in a Chinese Han population.<h4>Methodology/principal findings</h4>Four single-nucleotide polymorphism (SNPs) rs2227981 and rs10204525 of PD-1, rs1970000 of PD-L1 and rs7854303 of PD-L2 were genotyped in 405 Behcet's patients and 414 age-, sex-, ethnic-matched healthy controls using polymerase chain reaction-r2011-01-01T00:00:00Z20112025-04-26T06:18:18.987Z2019-03-26T23:16:22ZS-EPMC31984432203941010.1371/journal.pone.0025345