{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(1)"],"submitter":["Ohrfelt A"],"pubmed_abstract":["<h4>Background</h4>Novel biomarkers are important for identifying as well as differentiating subcortical vascular dementia (SVD) and Alzheimer's disease (AD) at an early stage in the disease process.<h4>Methods</h4>In two independent cohorts, a multiplex immunoassay was utilized to analyze 90 proteins in cerebrospinal fluid (CSF) samples from dementia patients and patients at risk of developing dementia (mild cognitive impairment).<h4>Results</h4>The levels of several CSF proteins were increased in SVD and its incipient state, and in moderate-to-severe AD compared with the control group. In contrast, some CSF proteins were altered in AD, but not in SVD. The levels of heart-type fatty acid binding protein (H-FABP) were consistently increased in all groups with dementia but only in some of their incipient states.<h4>Conclusions</h4>In summary, these results support the notion that SVD and AD are driven by different pathophysiological mechanisms reflected in the CSF protein profile and that H-FABP in CSF is a general marker of neurodegeneration."],"journal":["Dementia and geriatric cognitive disorders extra"],"pagination":["31-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3199889"],"repository":["biostudies-literature"],"pubmed_title":["Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease."],"pmcid":["PMC3199889"],"pubmed_authors":["Simon A","Devanarayan V","Wallin A","Holder D","Potter W","Smith AD","Andreasson U","Zetterberg H","Edman A","Seeburger J","Ohrfelt A","Blennow K"],"additional_accession":[]},"is_claimable":false,"name":"Screening for new biomarkers for subcortical vascular dementia and Alzheimer's disease.","description":"<h4>Background</h4>Novel biomarkers are important for identifying as well as differentiating subcortical vascular dementia (SVD) and Alzheimer's disease (AD) at an early stage in the disease process.<h4>Methods</h4>In two independent cohorts, a multiplex immunoassay was utilized to analyze 90 proteins in cerebrospinal fluid (CSF) samples from dementia patients and patients at risk of developing dementia (mild cognitive impairment).<h4>Results</h4>The levels of several CSF proteins were increased in SVD and its incipient state, and in moderate-to-severe AD compared with the control group. In contrast, some CSF proteins were altered in AD, but not in SVD. The levels of heart-type fatty acid binding protein (H-FABP) were consistently increased in all groups with dementia but only in some of their incipient states.<h4>Conclusions</h4>In summary, these results support the notion that SVD and AD are driven by different pathophysiological mechanisms reflected in the CSF protein profile and that H-FABP in CSF is a general marker of neurodegeneration.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2025-07-02T03:05:02.053Z","creation":"2025-07-02T03:05:02.053Z"},"accession":"S-EPMC3199889","cross_references":{"pubmed":["22163231"],"doi":["10.1159/000323417"]}}