{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pathania S"],"funding":["NIAID NIH HHS","NHGRI NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["235-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3200447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR."],"journal":["Molecular cell"],"pubmed_title":["BRCA1 is required for postreplication repair after UV-induced DNA damage."],"pmcid":["PMC3200447"],"funding_grant_id":["RC1 CA145867","P30 AI060354","R01 CA095175","R01 GM073894","P01NS047572","R21 CA144017","P50 HG004233","R01 CA103920-05","T32 GM007753","R01 CA103920","P50HG004233"],"pubmed_authors":["Scully R","Adelmant GO","Hill SJ","Pathania S","Livingston DM","Marto JA","Nguyen J","Feunteun J"],"additional_accession":[]},"is_claimable":false,"name":"BRCA1 is required for postreplication repair after UV-induced DNA damage.","description":"BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2024-11-20T22:07:10.891Z","creation":"2019-03-27T00:45:21Z"},"accession":"S-EPMC3200447","cross_references":{"pubmed":["21963239"],"doi":["10.1016/j.molcel.2011.09.002"]}}