{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lachance DH"],"funding":["NCI NIH HHS"],"pagination":["574-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3202152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["174(5)"],"pubmed_abstract":["Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma."],"journal":["American journal of epidemiology"],"pubmed_title":["Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking."],"pmcid":["PMC3202152"],"funding_grant_id":["P50 CA097257","P50 CA108786","P50 CA108961","5P50CA108786-4","P50CA097257","R01 CA052689","R01CA52689"],"pubmed_authors":["Wrensch MR","Buckner JC","Lachance DH","Patoka JS","Ali-Osman F","Wang F","Kollmeyer TM","Rice T","Wiencke JK","Davis F","Worra JB","Jenkins RB","Johnson DR","Kosel ML","Xiao Y","O'Neill BP","Stoddard SM","Sprau DJ","Il'yasova D","Wiemels JL","Yang P","Rynearson AL","Fridley BL","McCoy LS","Decker PA","McCarthy B"],"additional_accession":[]},"is_claimable":false,"name":"Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.","description":"Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2024-11-06T16:21:24.461Z","creation":"2019-03-27T00:45:24Z"},"accession":"S-EPMC3202152","cross_references":{"pubmed":["21742680"],"doi":["10.1093/aje/kwr124"]}}