{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ortiz AM"],"funding":["CCR NIH HHS","NCRR NIH HHS","NIAID NIH HHS","NCI NIH HHS","PHS HHS"],"pagination":["4433-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3204830"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(11)"],"pubmed_abstract":["CD4+ T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion during chronic HIV infection is a hallmark of disease progression. However, the relative contribution of CD4+ T cells as mediators of antiviral immune responses and targets for virus replication is still unclear. Here, we have generated data in SIV-infected rhesus macaques (RMs) that suggest that CD4+ T cells are essential in establishing control of virus replication during acute infection. To directly assess the role of CD4+ T cells during primary SIV infection, we in vivo depleted these cells from RMs prior to infecting the primates with a pathogenic strain of SIV. Compared with undepleted animals, CD4+ lymphocyte-depleted RMs showed a similar peak of viremia, but did not manifest any post-peak de"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques."],"pmcid":["PMC3204830"],"funding_grant_id":["R37 AI066998","HHSN261200800001E","HHSN261200800001C","P30 AI045008","RR-00165","P51 RR000165","261200800001E","AI-66998","R01 AI066998"],"pubmed_authors":["Little DM","Yi Y","Paiardini M","Hao XP","Ansari AA","Collman RG","Cramer EM","Klatt NR","Tabb B","Gonzalez-Scarano F","Brenchley JM","Estes JD","Ryzhova E","Else JG","Li B","Sternberg L","Ratcliffe S","Derdeyn CA","Lawson B","Carnathan PM","Silvestri G","Ortiz AM","Engram JC"],"additional_accession":[]},"is_claimable":false,"name":"Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.","description":"CD4+ T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion during chronic HIV infection is a hallmark of disease progression. However, the relative contribution of CD4+ T cells as mediators of antiviral immune responses and targets for virus replication is still unclear. Here, we have generated data in SIV-infected rhesus macaques (RMs) that suggest that CD4+ T cells are essential in establishing control of virus replication during acute infection. To directly assess the role of CD4+ T cells during primary SIV infection, we in vivo depleted these cells from RMs prior to infecting the primates with a pathogenic strain of SIV. Compared with undepleted animals, CD4+ lymphocyte-depleted RMs showed a similar peak of viremia, but did not manifest any post-peak de","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2025-04-21T18:14:12.19Z","creation":"2019-03-27T00:45:31Z"},"accession":"S-EPMC3204830","cross_references":{"pubmed":["22005304"],"doi":["10.1172/jci46023","10.1172/JCI46023"]}}