{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang X"],"funding":["NINDS NIH HHS"],"pagination":["4362-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3204834"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(11)"],"pubmed_abstract":["Stroke is the third leading cause of death in the United States. Fewer than 5% of patients benefit from the only intervention approved to treat stroke. Thus, there is an enormous need to identify new therapeutic targets. The role of inducible cyclooxygenase (COX-2) activity in stroke and other neurologic diseases is complex, as both activation and sustained inhibition can engender cerebral injury. Whether COX-2 induces cerebroprotective or injurious effects is probably dependent on which downstream prostaglandin receptors are activated. Here, we investigated the function of the PGE2 receptor EP4 in a mouse model of cerebral ischemia. Systemic administration of a selective EP4 agonist after ischemia reduced infarct volume and ameliorated long-term behavioral deficits. Expression of EP4 was "],"journal":["The Journal of clinical investigation"],"pubmed_title":["Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia."],"pmcid":["PMC3204834"],"funding_grant_id":["R01 NS045727","R01NS045727"],"pubmed_authors":["Andreasson K","Wang Q","Pan T","Liang X","Lin L","Anacker C","Merchant M","Woodling NS"],"additional_accession":[]},"is_claimable":false,"name":"Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.","description":"Stroke is the third leading cause of death in the United States. Fewer than 5% of patients benefit from the only intervention approved to treat stroke. Thus, there is an enormous need to identify new therapeutic targets. The role of inducible cyclooxygenase (COX-2) activity in stroke and other neurologic diseases is complex, as both activation and sustained inhibition can engender cerebral injury. Whether COX-2 induces cerebroprotective or injurious effects is probably dependent on which downstream prostaglandin receptors are activated. Here, we investigated the function of the PGE2 receptor EP4 in a mouse model of cerebral ischemia. Systemic administration of a selective EP4 agonist after ischemia reduced infarct volume and ameliorated long-term behavioral deficits. Expression of EP4 was ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2025-04-04T07:25:27.158Z","creation":"2019-03-27T00:45:32Z"},"accession":"S-EPMC3204834","cross_references":{"pubmed":["21965326"],"doi":["10.1172/jci46279","10.1172/JCI46279"]}}