{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(10)"],"submitter":["Buchse T"],"pubmed_abstract":["The Cbl-interacting 85-kDa protein (CIN85) plays an important role as a negative regulator of signaling pathways induced by receptor tyrosine kinases. By assembling multiprotein complexes this versatile adaptor enhances receptor tyrosine kinase-activated clathrin-mediated endocytosis and reduces phosphatidylinositol-3-kinase-induced phosphatidylinositol-3,4,5-trisphosphate production. Here we report the expression of CIN85 in primary splenic B lymphocytes and the B-lymphoma cell lines WEHI 231 and Ba/F3. Cross-linking of the B cell antigen receptor resulted in an increased association of CIN85 with the ubiquitin ligase Cbl. Through a systematic pull-down proteomics approach we identified 51 proteins that interact with CIN85 in B cells, including proteins not shown previously to be CIN85-as"],"journal":["Molecular & cellular proteomics : MCP"],"pagination":["M110.006239"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3205855"],"repository":["biostudies-literature"],"pubmed_title":["CIN85 interacting proteins in B cells-specific role for SHIP-1."],"pmcid":["PMC3205855"],"pubmed_authors":["Horras N","Mikkat S","Lenfert E","Tiedge M","Korbel S","Krystal G","Krause E","Schumann M","Buchse T"],"additional_accession":[]},"is_claimable":false,"name":"CIN85 interacting proteins in B cells-specific role for SHIP-1.","description":"The Cbl-interacting 85-kDa protein (CIN85) plays an important role as a negative regulator of signaling pathways induced by receptor tyrosine kinases. By assembling multiprotein complexes this versatile adaptor enhances receptor tyrosine kinase-activated clathrin-mediated endocytosis and reduces phosphatidylinositol-3-kinase-induced phosphatidylinositol-3,4,5-trisphosphate production. Here we report the expression of CIN85 in primary splenic B lymphocytes and the B-lymphoma cell lines WEHI 231 and Ba/F3. Cross-linking of the B cell antigen receptor resulted in an increased association of CIN85 with the ubiquitin ligase Cbl. Through a systematic pull-down proteomics approach we identified 51 proteins that interact with CIN85 in B cells, including proteins not shown previously to be CIN85-as","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2025-04-18T17:24:56.302Z","creation":"2019-06-05T16:51:31Z"},"accession":"S-EPMC3205855","cross_references":{"pubmed":["21725061"],"doi":["10.1074/mcp.m110.006239","10.1074/mcp.M110.006239"]}}