{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Srivastava S"],"funding":["NIAID NIH HHS"],"pagination":["1951-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3209814"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["204(12)"],"pubmed_abstract":["<h4>Background</h4>It is believed that nonadherence is the proximate cause of multidrug-resistant tuberculosis (MDR-tuberculosis) emergence. The level of nonadherence associated with emergence of MDR-tuberculosis is unknown. Performance of a randomized controlled trial in which some patients are randomized to nonadherence would be unethical; therefore, other study designs should be utilized.<h4>Methods</h4>We performed hollow fiber studies for both bactericidal and sterilizing effect, with inoculum spiked with 0.5% rifampin- and isoniazid-resistant isogenic strains in some experiments. Standard therapy was administered daily for 28-56 days, with extents of nonadherence varying between 0% and 100%. Sizes of drug-resistant populations were compared using analysis of variance. We also explore"],"journal":["The Journal of infectious diseases"],"pubmed_title":["Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability."],"pmcid":["PMC3209814"],"funding_grant_id":["R01AI079497","R01 AI079497"],"pubmed_authors":["Srivastava S","Meek C","Leff R","Pasipanodya JG","Gumbo T"],"additional_accession":[]},"is_claimable":false,"name":"Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability.","description":"<h4>Background</h4>It is believed that nonadherence is the proximate cause of multidrug-resistant tuberculosis (MDR-tuberculosis) emergence. The level of nonadherence associated with emergence of MDR-tuberculosis is unknown. Performance of a randomized controlled trial in which some patients are randomized to nonadherence would be unethical; therefore, other study designs should be utilized.<h4>Methods</h4>We performed hollow fiber studies for both bactericidal and sterilizing effect, with inoculum spiked with 0.5% rifampin- and isoniazid-resistant isogenic strains in some experiments. Standard therapy was administered daily for 28-56 days, with extents of nonadherence varying between 0% and 100%. Sizes of drug-resistant populations were compared using analysis of variance. We also explore","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-04T22:24:06.807Z","creation":"2019-03-27T00:45:46Z"},"accession":"S-EPMC3209814","cross_references":{"pubmed":["22021624"],"doi":["10.1093/infdis/jir658"]}}