{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Block AS"],"funding":["NICHD NIH HHS","NCRR NIH HHS"],"pagination":["711-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3210485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(7)"],"pubmed_abstract":["<h4>Background</h4>Prostasomes are exosome-like vesicles that are secreted by the prostate and incorporated into semen during ejaculation. Human prostasomes are proposed to function in regulation of sperm function, immunosuppression, and prostate cancer progression. Previously, we identified galectin-3 on the surface of prostasomes. Galectin-3 is a β-galactoside binding protein involved in immunomodulation, cell interactions, and cancer progression, including prostate cancer. Functional characterization of galectin-3 in a given biological environment includes identification of its target glycoprotein ligands.<h4>Methods</h4>Candidate galectin-3 ligands in prostasomes were identified by tandem mass spectrometry of proteins that co-purified with galectin-3 during lactose affinity chromatogra"],"journal":["The Prostate"],"pubmed_title":["Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen."],"pmcid":["PMC3210485"],"funding_grant_id":["HD50540","R01 HD050540","P20 RR-16460","P20 RR016460","R01 HD050540-04"],"pubmed_authors":["Mahadevan M","Saraswati S","Block AS","Lichti CF","Diekman AB"],"additional_accession":[]},"is_claimable":false,"name":"Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen.","description":"<h4>Background</h4>Prostasomes are exosome-like vesicles that are secreted by the prostate and incorporated into semen during ejaculation. Human prostasomes are proposed to function in regulation of sperm function, immunosuppression, and prostate cancer progression. Previously, we identified galectin-3 on the surface of prostasomes. Galectin-3 is a β-galactoside binding protein involved in immunomodulation, cell interactions, and cancer progression, including prostate cancer. Functional characterization of galectin-3 in a given biological environment includes identification of its target glycoprotein ligands.<h4>Methods</h4>Candidate galectin-3 ligands in prostasomes were identified by tandem mass spectrometry of proteins that co-purified with galectin-3 during lactose affinity chromatogra","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-04-21T19:59:37.543Z","creation":"2019-06-05T16:52:25Z"},"accession":"S-EPMC3210485","cross_references":{"pubmed":["21031433"],"doi":["10.1002/pros.21287"]}}