{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(11)"],"submitter":["Morandi A"],"pubmed_abstract":["Breast cancer is the second leading cause of cancer-related deaths in western countries. Colony-Stimulating Factor-1 (CSF-1) and its receptor (CSF-1R) regulate macrophage and osteoclast production, trophoblast implantation and mammary gland development. The expression of CSF-1R and/or CSF-1 strongly correlates with poor prognosis in several human epithelial tumors, including breast carcinomas. We demonstrate that CSF-1 and CSF-1R are expressed, although at different levels, in 16/17 breast cancer cell lines tested with no differences among molecular subtypes. The role of CSF-1/CSF-1R in the proliferation of breast cancer cells was then studied in MDAMB468 and SKBR3 cells belonging to different subtypes. CSF-1 administration induced ERK1/2 phosphorylation and enhanced cell proliferation in "],"journal":["PloS one"],"pagination":["e27450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3212567"],"repository":["biostudies-literature"],"pubmed_title":["The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines."],"pmcid":["PMC3212567"],"pubmed_authors":["Barbetti V","Morandi A","Rovida E","Riverso M","Dello Sbarba P"],"additional_accession":[]},"is_claimable":false,"name":"The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines.","description":"Breast cancer is the second leading cause of cancer-related deaths in western countries. Colony-Stimulating Factor-1 (CSF-1) and its receptor (CSF-1R) regulate macrophage and osteoclast production, trophoblast implantation and mammary gland development. The expression of CSF-1R and/or CSF-1 strongly correlates with poor prognosis in several human epithelial tumors, including breast carcinomas. We demonstrate that CSF-1 and CSF-1R are expressed, although at different levels, in 16/17 breast cancer cell lines tested with no differences among molecular subtypes. The role of CSF-1/CSF-1R in the proliferation of breast cancer cells was then studied in MDAMB468 and SKBR3 cells belonging to different subtypes. CSF-1 administration induced ERK1/2 phosphorylation and enhanced cell proliferation in ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-05-29T22:11:49.718Z","creation":"2025-05-29T22:11:49.718Z"},"accession":"S-EPMC3212567","cross_references":{"pubmed":["22096574"],"doi":["10.1371/journal.pone.0027450"]}}