biostudies-literatureMarcocci CNIDDK NIH HHS2766-72https://www.ebi.ac.uk/biostudies/studies/S-EPMC3214593biostudies-literatureUnknown94(8)<h4>Context</h4>Patients with persistent primary hyperparathyroidism (PHPT) after parathyroidectomy or with contraindications to parathyroidectomy often require chronic treatment for hypercalcemia.<h4>Objective</h4>The objective of the study was to assess the ability of the calcimimetic, cinacalcet, to reduce serum calcium in patients with intractable PHPT.<h4>Design</h4>This was an open-label, single-arm study comprising a titration phase of variable duration (2-16 wk) and a maintenance phase of up to 136 wk.<h4>Setting</h4>The study was conducted at 23 centers in Europe, the United States, and Canada.<h4>Patients</h4>The study included 17 patients with intractable PHPT and serum calcium greater than 12.5 mg/dl (3.1 mmol/liter).<h4>Intervention</h4>During the titration phase, cinacalcet dThe Journal of clinical endocrinology and metabolismCinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism.PMC3214593R01 DK032333Henzen CCheng SOrgiazzi JLu JShoback DBilezikian JSterling LRMarcocci CChanson PPeacock MFernandez-Cruz LfalseCinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism.<h4>Context</h4>Patients with persistent primary hyperparathyroidism (PHPT) after parathyroidectomy or with contraindications to parathyroidectomy often require chronic treatment for hypercalcemia.<h4>Objective</h4>The objective of the study was to assess the ability of the calcimimetic, cinacalcet, to reduce serum calcium in patients with intractable PHPT.<h4>Design</h4>This was an open-label, single-arm study comprising a titration phase of variable duration (2-16 wk) and a maintenance phase of up to 136 wk.<h4>Setting</h4>The study was conducted at 23 centers in Europe, the United States, and Canada.<h4>Patients</h4>The study included 17 patients with intractable PHPT and serum calcium greater than 12.5 mg/dl (3.1 mmol/liter).<h4>Intervention</h4>During the titration phase, cinacalcet d2009-01-01T00:00:00Z2009 Aug2026-04-12T23:44:05.975Z2019-03-27T00:01:09ZS-EPMC32145931947062010.1210/jc.2008-2640