{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(11)"],"submitter":["Pepin D"],"pubmed_abstract":["Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types. In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new diagnostic and prognostic biomarkers. However, little is known about the contributions of KLK5, 6 and 10 to ovarian cancer pathophysiology.In this study, a panel of 13 human ovarian cancer cell lines was screened by ELISA for secretion of KLK5, 6, 8, 10, 13, and 14. The ES-2 cell line, devoid of these kallikreins, was transfected with expression vectors of KLK5, 6 and 10 individually or in pairs. Co-expression of KLK5, 6 and 10 was correlated with lessened aggressivity of ovarian cancer cell lines as defined by reduced colony formation in soft ag"],"journal":["PloS one"],"pagination":["e26075"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3216928"],"repository":["biostudies-literature"],"pubmed_title":["Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model."],"pmcid":["PMC3216928"],"pubmed_authors":["Pepin D","Shao ZQ","Vanderhyden BC","Chu CW","Huppe G","Sharif Z","Wakefield A"],"additional_accession":[]},"is_claimable":false,"name":"Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model.","description":"Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types. In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new diagnostic and prognostic biomarkers. However, little is known about the contributions of KLK5, 6 and 10 to ovarian cancer pathophysiology.In this study, a panel of 13 human ovarian cancer cell lines was screened by ELISA for secretion of KLK5, 6, 8, 10, 13, and 14. The ES-2 cell line, devoid of these kallikreins, was transfected with expression vectors of KLK5, 6 and 10 individually or in pairs. Co-expression of KLK5, 6 and 10 was correlated with lessened aggressivity of ovarian cancer cell lines as defined by reduced colony formation in soft ag","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-07-09T03:05:03.567Z","creation":"2025-07-09T03:05:03.567Z"},"accession":"S-EPMC3216928","cross_references":{"pubmed":["22102857"],"doi":["10.1371/journal.pone.0026075"]}}