{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McKay GJ"],"funding":["Economic and Social Research Council","Intramural NIH HHS","British Heart Foundation","NEI NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["1407-16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3217135"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(12)"],"pubmed_abstract":["Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APOε4 (odds ratio [OR] = 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P = 4.41×10(-11) ) and APOε2 (OR = 1.83 for homozygote carriers; CI: 1.04-3.23; P = 0.04), following adjustment for age group and sex within each study and smoking status. No evidence of interaction between APOE and sex or smoking was found. Ever smokers had s"],"journal":["Human mutation"],"pubmed_title":["Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies."],"pmcid":["PMC3217135"],"funding_grant_id":["MC_PC_U127584475","G0700704B","R01 EY016862","G0000067","MC_U127584475","ZIA EY000475","ES/G007438/1","NF-SI-0507-10094","G0601354","MC_PC_U127561128","RG/10/12/28456","R01 EY011309"],"pubmed_authors":["Dasari S","Seland JH","Abecasis GR","Soubrane G","Gorin MB","Othman M","Yates JR","Chen W","Klaver CC","Vingerling JR","Klein ML","Seddon JM","Moore AT","Hayward C","Ennis S","Kanda A","Wright AF","Fletcher AE","Fritsche LG","Weeks DE","Ho L","Patterson CC","Attia J","Rahu M","Francis PJ","Silvestri G","Weber BH","Vioque J","Webster AR","Tomazzoli L","Peter I","Young IS","Lotery AJ","Sofat R","Cipriani V","Keilhauer CN","McKay GJ","Kuo CL","Guymer RH","Chakravarthy U","Topouzis F","Thakkinstian A","Baird PN","Hingorani AD","de Jong PT","Swaroop A","Stambolian D","Orlin A","Sawitzke J","Dean M"],"additional_accession":[]},"is_claimable":false,"name":"Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.","description":"Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APOε4 (odds ratio [OR] = 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P = 4.41×10(-11) ) and APOε2 (OR = 1.83 for homozygote carriers; CI: 1.04-3.23; P = 0.04), following adjustment for age group and sex within each study and smoking status. No evidence of interaction between APOE and sex or smoking was found. Ever smokers had s","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2026-04-15T11:23:52.109Z","creation":"2026-04-07T13:55:36.254Z"},"accession":"S-EPMC3217135","cross_references":{"pubmed":["21882290"],"doi":["10.1002/humu.21577"]}}