{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hollis-Moffatt JE"],"funding":["NCRR NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS"],"pagination":["R85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3218899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Introduction
The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout. There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples.Methods
Rs3733591 was genotyped across gout patients (n = 229, 232 and 327 NZ Māori, Pacific Island and Caucasian samples, respectively) and non-gout controls (n = 343, 174 and 638 Māori, Pacific Island and Caucasian samples, respectively). Further Caucasian sample sets consisting of 67 cases and 4,712 controls as well as 153 cases and 6,969 controls were obtained from t"],"journal":["Arthritis research & therapy"],"pubmed_title":["The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity."],"pmcid":["PMC3218899"],"funding_grant_id":["N01-HC-55021","N01-HC-55020","R01 HL59367","U01HG004402","N01 HC-55016","N01-HC-55022","N01-HC-55018","UL1RR025005","N01-HC-55015","R01 HL086694","N01-HC-55019","R01 HL087641"],"pubmed_authors":["Highton J","Gow PJ","Harrison AA","Stamp LK","Hollis-Moffatt JE","Dalbeth N","Jones PB","Merriman TR"],"additional_accession":[]},"is_claimable":false,"name":"The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity.","description":"Introduction
The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout. There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Caucasian samples.Methods
Rs3733591 was genotyped across gout patients (n = 229, 232 and 327 NZ Māori, Pacific Island and Caucasian samples, respectively) and non-gout controls (n = 343, 174 and 638 Māori, Pacific Island and Caucasian samples, respectively). Further Caucasian sample sets consisting of 67 cases and 4,712 controls as well as 153 cases and 6,969 controls were obtained from t","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-21T14:10:19.883Z","creation":"2019-06-05T16:53:34Z"},"accession":"S-EPMC3218899","cross_references":{"pubmed":["21658257"],"doi":["10.1186/ar3356"]}}