{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(3)"],"submitter":["Ricci Z"],"pubmed_abstract":["<h4>Introduction</h4>The aim of the study was to evaluate the effects of high-dose fenoldopam, a selective dopamine-1 receptor, on renal function and organ perfusion during cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD).<h4>Methods</h4>A prospective single-center randomized double-blind controlled trial was conducted in a pediatric cardiac surgery department. We randomized infants younger than 1 year with CHD and biventricular anatomy (with exclusion of isolated ventricular and atrial septal defect) to receive blindly a continuous infusion of fenoldopam at 1 μg/kg/min or placebo during CPB. Perioperative urinary and plasma levels of neutrophil gelatinase-associated lipocaline (NGAL), cystatin C (CysC), and creatinine were measured to assess renal injury after C"],"journal":["Critical care (London, England)"],"pagination":["R160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3219034"],"repository":["biostudies-literature"],"pubmed_title":["High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery."],"pmcid":["PMC3219034"],"pubmed_authors":["Ricci Z","Muraca M","Cogo P","Favia I","Garisto C","Morelli S","Picardo S","Luciano R","Di Chiara L"],"additional_accession":[]},"is_claimable":false,"name":"High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery.","description":"<h4>Introduction</h4>The aim of the study was to evaluate the effects of high-dose fenoldopam, a selective dopamine-1 receptor, on renal function and organ perfusion during cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD).<h4>Methods</h4>A prospective single-center randomized double-blind controlled trial was conducted in a pediatric cardiac surgery department. We randomized infants younger than 1 year with CHD and biventricular anatomy (with exclusion of isolated ventricular and atrial septal defect) to receive blindly a continuous infusion of fenoldopam at 1 μg/kg/min or placebo during CPB. Perioperative urinary and plasma levels of neutrophil gelatinase-associated lipocaline (NGAL), cystatin C (CysC), and creatinine were measured to assess renal injury after C","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jun","modification":"2025-04-21T14:11:39.685Z","creation":"2019-03-27T00:46:06Z"},"accession":"S-EPMC3219034","cross_references":{"pubmed":["21714857"],"doi":["10.1186/cc10295"]}}