{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin Y"],"funding":["NIDCR NIH HHS","NCRR NIH HHS","NCI NIH HHS"],"pagination":["40104-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3220531"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["286(46)"],"pubmed_abstract":["MicroRNA-138 is one of the most frequently down-regulated microRNAs in cancer. We recently identified 51 candidate targets of microRNA-138 (Jiang, L., Dai, Y., Liu, X., Wang, C., Wang, A., Chen, Z., Heidbreder, C. E., Kolokythas, A., and Zhou, X. (2011) Hum. Genet. 129, 189-197). Among these candidates, Fos-like antigen 1 (FOSL1) is a member of Fos gene family and is a known proto-oncogene. In this study, we first confirmed the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma cell lines. We then demonstrated the effect of this microRNA-138-FOSL1 regulatory module on downstream genes (homolog of Snail 2 (Snai2) expression and the Snai2-mediated repression of E-cadherin expression), as well as its contributions to tumorigenesis. The microRNA-138-directed recruitment "],"journal":["The Journal of biological chemistry"],"pubmed_title":["Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma."],"pmcid":["PMC3220531"],"funding_grant_id":["CA139596","K22 DE014847","UL1RR029879","CA135992","T32  DE018381","R03 CA135992","DE014847","UL1 RR029879","R01 CA139596"],"pubmed_authors":["Liu X","Wang A","Chen Z","Wang C","Yu D","Mu W","Jin Y","Zhou X","Dai Y"],"additional_accession":[]},"is_claimable":false,"name":"Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma.","description":"MicroRNA-138 is one of the most frequently down-regulated microRNAs in cancer. We recently identified 51 candidate targets of microRNA-138 (Jiang, L., Dai, Y., Liu, X., Wang, C., Wang, A., Chen, Z., Heidbreder, C. E., Kolokythas, A., and Zhou, X. (2011) Hum. Genet. 129, 189-197). Among these candidates, Fos-like antigen 1 (FOSL1) is a member of Fos gene family and is a known proto-oncogene. In this study, we first confirmed the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma cell lines. We then demonstrated the effect of this microRNA-138-FOSL1 regulatory module on downstream genes (homolog of Snail 2 (Snai2) expression and the Snai2-mediated repression of E-cadherin expression), as well as its contributions to tumorigenesis. The microRNA-138-directed recruitment ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2026-05-04T08:26:00.784Z","creation":"2025-07-01T03:05:40.116Z"},"accession":"S-EPMC3220531","cross_references":{"pubmed":["21969367"],"doi":["10.1074/jbc.C111.296707","10.1074/jbc.c111.296707"]}}