{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["ten Tusscher KH"],"pubmed_abstract":["<h4>Background</h4>Sexual reproduction has classically been considered as a barrier to the buildup of discrete phenotypic differentiation. This notion has been confirmed by models of sympatric speciation in which a fixed genetic architecture and a linear genotype phenotype mapping were assumed. In this paper we study the influence of a flexible genetic architecture and non-linear genotype phenotype map on differentiation under sexual reproduction.We use an individual based model in which organisms have a genome containing genes and transcription factor binding sites. Mutations involve single genes or binding sites or stretches of genome. The genome codes for a regulatory network that determines the gene expression pattern and hence the phenotype of the organism, resulting in a non-linear g"],"journal":["BMC evolutionary biology"],"pagination":["159"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3224660"],"repository":["biostudies-literature"],"pubmed_title":["The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation."],"pmcid":["PMC3224660"],"pubmed_authors":["ten Tusscher KH","Hogeweg P"],"additional_accession":[]},"is_claimable":false,"name":"The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation.","description":"<h4>Background</h4>Sexual reproduction has classically been considered as a barrier to the buildup of discrete phenotypic differentiation. This notion has been confirmed by models of sympatric speciation in which a fixed genetic architecture and a linear genotype phenotype mapping were assumed. In this paper we study the influence of a flexible genetic architecture and non-linear genotype phenotype map on differentiation under sexual reproduction.We use an individual based model in which organisms have a genome containing genes and transcription factor binding sites. Mutations involve single genes or binding sites or stretches of genome. The genome codes for a regulatory network that determines the gene expression pattern and hence the phenotype of the organism, resulting in a non-linear g","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jul","modification":"2025-05-29T22:28:36.663Z","creation":"2025-05-29T22:28:36.663Z"},"accession":"S-EPMC3224660","cross_references":{"pubmed":["19589138"],"doi":["10.1186/1471-2148-9-159"]}}