{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schnabel RB"],"funding":["NCATS NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NIDA NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","NINDS NIH HHS","NCI NIH HHS"],"pagination":["557-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3224824"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(5)"],"pubmed_abstract":["<h4>Background</h4>The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.<h4>Methods and results</h4>We examined a panel of approximately 50,000 common single-nucleotide polymorphisms (SNPs) in 2095 cardiovascular candidate genes and AF in 3 cohorts with participants of European (n=18,524; 2260 cases) or African American descent (n=3662; 263 cases) in the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource. Results in whites were followed up in the German Competence Network for AF (n=906, 468 cases). The top result was assessed in relation to incident ischemic stroke in the Cohorts for Heart and Aging Research in Genomic Epidemiology Stroke"],"journal":["Circulation. Cardiovascular genetics"],"pubmed_title":["Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project."],"pmcid":["PMC3224824"],"funding_grant_id":["1R01HL092577","N01 HC085086","N01-HC-25195","K24 HL105780","HL104156","M01RR00069","R01 AG031287","DA027021","R01 HL059367","HHSN268200900055C","UL1 RR025005","N01 HC075150","AG08122","T32 HL007575","N01 CN015103","NS17950","R01HL087641","UL1 TR000124","R01 HL093029","N02 HL064278","N01 HC055020","R01 HL092577","N01 HC055021","N01 HC055022","N01 HC055222","R01HL59367","HL105780","R01HL093029","RC1 HL099452","M01 RR000069","DK063491","P30 DK063491","N01 HC065226","R01 HL086694","N01-HC-55021","N01-HC-55020","RC1HL099452","N01-HC-75150","R01 HL104156","N01-HC-55222","U01 HG004402","R01-HL080295","RC1 HL101056","N01-HC-55022","N01-HC-85079","U01 HL080295","N01-HC-65226","U01HL080295","N01 HC055015","N01 HC025195","N01 HC055016","N01-HC-85080","L30 HL097675","N01 HC055018","N01 HC055019","N02-HL-6-4278","N01 HC035129","N01-HC-55018","RC1HL101056","N01-HC-55016","N01-HC-85085","N01-HC-55015","N01-HC-85086","N01-HC-85083","AG031287","N01-HC-85084","N01-HC-85081","R01 AG027002","N01-HC-85082","R01 HL087652","N01-HC-55019","R01 AG008122","R01HL086694","R01 AG028321","N01 HC015103","AG028321","R01 NS017950","UL1RR025005","R21 DA027021","R01 HL080295","R01 AG033193","U01HG004402","AG033193","N01 HC085079","N01 HC045133","R01HL087652","R01AG027002","R01 HL087641"],"pubmed_authors":["Schnabel RB","Rotter JI","Wichmann HE","Kerr KF","Alkylbekova EL","Soliman EZ","Candidate Gene Association Resource (CARe) Atrial Fibrillation/Electrocardiography Working Group","Sinner MF","Lunetta KL","Sotoodehnia N","Deo R","Wilson JG","Mosley TH","Wolf PA","Mehra R","Lubitz SA","Lloyd-Jones DM","Alonso A","Benjamin EJ","Marcus GM","Farlow DN","Young TR","Ellinor PT","Heckbert SR","Seshadri S","Arking DE","Kaab S","Levy D","Fox ER","Muller-Nurasyid M","Newton-Cheh C","Glazer NL","Breteler MM","Magnani JW"],"additional_accession":[]},"is_claimable":false,"name":"Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.","description":"<h4>Background</h4>The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.<h4>Methods and results</h4>We examined a panel of approximately 50,000 common single-nucleotide polymorphisms (SNPs) in 2095 cardiovascular candidate genes and AF in 3 cohorts with participants of European (n=18,524; 2260 cases) or African American descent (n=3662; 263 cases) in the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource. Results in whites were followed up in the German Competence Network for AF (n=906, 468 cases). The top result was assessed in relation to incident ischemic stroke in the Cohorts for Heart and Aging Research in Genomic Epidemiology Stroke","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2026-05-01T01:18:39.693Z","creation":"2026-04-07T16:29:30.576Z"},"accession":"S-EPMC3224824","cross_references":{"pubmed":["21846873"],"doi":["10.1161/CIRCGENETICS.110.959197","10.1161/circgenetics.110.959197"]}}