biostudies-literatureSchnabel RBNCATS NIH HHSNIA NIH HHSNCRR NIH HHSNIDDK NIH HHSNIDA NIH HHSNHLBI NIH HHSNHGRI NIH HHSNINDS NIH HHSNCI NIH HHS557-64https://www.ebi.ac.uk/biostudies/studies/S-EPMC3224824biostudies-literatureUnknown4(5)<h4>Background</h4>The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.<h4>Methods and results</h4>We examined a panel of approximately 50,000 common single-nucleotide polymorphisms (SNPs) in 2095 cardiovascular candidate genes and AF in 3 cohorts with participants of European (n=18,524; 2260 cases) or African American descent (n=3662; 263 cases) in the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource. Results in whites were followed up in the German Competence Network for AF (n=906, 468 cases). The top result was assessed in relation to incident ischemic stroke in the Cohorts for Heart and Aging Research in Genomic Epidemiology StrokeCirculation. Cardiovascular geneticsLarge-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.PMC32248241R01HL092577N01 HC085086N01-HC-25195K24 HL105780HL104156M01RR00069R01 AG031287DA027021R01 HL059367HHSN268200900055CUL1 RR025005N01 HC075150AG08122T32 HL007575N01 CN015103NS17950R01HL087641UL1 TR000124R01 HL093029N02 HL064278N01 HC055020R01 HL092577N01 HC055021N01 HC055022N01 HC055222R01HL59367HL105780R01HL093029RC1 HL099452M01 RR000069DK063491P30 DK063491N01 HC065226R01 HL086694N01-HC-55021N01-HC-55020RC1HL099452N01-HC-75150R01 HL104156N01-HC-55222U01 HG004402R01-HL080295RC1 HL101056N01-HC-55022N01-HC-85079U01 HL080295N01-HC-65226U01HL080295N01 HC055015N01 HC025195N01 HC055016N01-HC-85080L30 HL097675N01 HC055018N01 HC055019N02-HL-6-4278N01 HC035129N01-HC-55018RC1HL101056N01-HC-55016N01-HC-85085N01-HC-55015N01-HC-85086N01-HC-85083AG031287N01-HC-85084N01-HC-85081R01 AG027002N01-HC-85082R01 HL087652N01-HC-55019R01 AG008122R01HL086694R01 AG028321N01 HC015103AG028321R01 NS017950UL1RR025005R21 DA027021R01 HL080295R01 AG033193U01HG004402AG033193N01 HC085079N01 HC045133R01HL087652R01AG027002R01 HL087641Schnabel RBRotter JIWichmann HEKerr KFAlkylbekova ELSoliman EZCandidate Gene Association Resource (CARe) Atrial Fibrillation/Electrocardiography Working GroupSinner MFLunetta KLSotoodehnia NDeo RWilson JGMosley THWolf PAMehra RLubitz SALloyd-Jones DMAlonso ABenjamin EJMarcus GMFarlow DNYoung TREllinor PTHeckbert SRSeshadri SArking DEKaab SLevy DFox ERMuller-Nurasyid MNewton-Cheh CGlazer NLBreteler MMMagnani JWfalseLarge-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.<h4>Background</h4>The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.<h4>Methods and results</h4>We examined a panel of approximately 50,000 common single-nucleotide polymorphisms (SNPs) in 2095 cardiovascular candidate genes and AF in 3 cohorts with participants of European (n=18,524; 2260 cases) or African American descent (n=3662; 263 cases) in the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource. Results in whites were followed up in the German Competence Network for AF (n=906, 468 cases). The top result was assessed in relation to incident ischemic stroke in the Cohorts for Heart and Aging Research in Genomic Epidemiology Stroke2011-01-01T00:00:00Z2011 Oct2026-05-01T01:18:39.693Z2026-04-07T16:29:30.576ZS-EPMC32248242184687310.1161/CIRCGENETICS.110.95919710.1161/circgenetics.110.959197