{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66(12)"],"submitter":["Fanos V"],"pubmed_abstract":["Although the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics."],"journal":["Clinics (Sao Paulo, Brazil)"],"pagination":["2141-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3226612"],"repository":["biostudies-literature"],"pubmed_title":["Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?"],"pmcid":["PMC3226612"],"pubmed_authors":["Fanos V","Pusceddu M","Dessi A","Marcialis MA"],"additional_accession":[]},"is_claimable":false,"name":"Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?","description":"Although the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2025-04-18T17:12:19.245Z","creation":"2019-06-05T16:54:48Z"},"accession":"S-EPMC3226612","cross_references":{"pubmed":["22189742"],"doi":["10.1590/s1807-59322011001200022"]}}