biostudies-literatureUnknown66(12)Fanos VAlthough the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics.Clinics (Sao Paulo, Brazil)2141-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3226612biostudies-literatureShould we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?PMC3226612Fanos VPusceddu MDessi AMarcialis MAfalseShould we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?Although the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics.2011-01-01T00:00:00Z20112025-04-18T17:12:19.245Z2019-06-05T16:54:48ZS-EPMC32266122218974210.1590/s1807-59322011001200022