biostudies-literatureUnknown16(9)Talat N<h4>Background</h4>Castleman's disease is a rare primary disease of the lymph nodes with limited available clinical information.<h4>Methods</h4>A systematic literature search identified 416 cases amenable to detailed analysis.<h4>Results</h4>In HIV(-) patients, centricity, pathology type, the presence of symptoms, gender, and age all predict outcome in univariate analyses. The 3-year disease-free survival (DFS) rate for patients with unicentric hyaline vascular disease (49.5% of cases, class I) was 92.5%, versus 45.7% for those with multicentric plasma cell disease (20.2% of cases, class III) and 78.0% for those with any other combination (22.6% of cases, class II) (p < .0001). HIV(+) patients (class IV) exclusively presented with multicentric plasma cell disease and had a 3-year DFS rate of only 27.8%. Kaposi's sarcoma and lymphoma were observed in 59.3% and 9.4% of HIV(+) patients and in 2.6% and 3.6% of HIV(-) patients (p < .0001). Paraneoplastic pemphigus and the syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes were observed exclusively in HIV(-) patients at a rate of 1.3% and 1.8%, respectively.<h4>Conclusion</h4>Clinical, pathological, and viral markers allow for the classification of Castleman's disease into groups with markedly different outcomes and disease associations.The oncologist1316-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC3228165biostudies-literatureCastleman's disease: systematic analysis of 416 patients from the literature.PMC3228165Talat NSchulte KMfalseCastleman's disease: systematic analysis of 416 patients from the literature.<h4>Background</h4>Castleman's disease is a rare primary disease of the lymph nodes with limited available clinical information.<h4>Methods</h4>A systematic literature search identified 416 cases amenable to detailed analysis.<h4>Results</h4>In HIV(-) patients, centricity, pathology type, the presence of symptoms, gender, and age all predict outcome in univariate analyses. The 3-year disease-free survival (DFS) rate for patients with unicentric hyaline vascular disease (49.5% of cases, class I) was 92.5%, versus 45.7% for those with multicentric plasma cell disease (20.2% of cases, class III) and 78.0% for those with any other combination (22.6% of cases, class II) (p < .0001). HIV(+) patients (class IV) exclusively presented with multicentric plasma cell disease and had a 3-year DFS rate of only 27.8%. Kaposi's sarcoma and lymphoma were observed in 59.3% and 9.4% of HIV(+) patients and in 2.6% and 3.6% of HIV(-) patients (p < .0001). Paraneoplastic pemphigus and the syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes were observed exclusively in HIV(-) patients at a rate of 1.3% and 1.8%, respectively.<h4>Conclusion</h4>Clinical, pathological, and viral markers allow for the classification of Castleman's disease into groups with markedly different outcomes and disease associations.2011-01-01T00:00:00Z20112021-02-20T14:42:52Z2019-03-27T00:46:34ZS-EPMC32281652176519110.1634/theoncologist.2011-0075