{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pido-Lopez J"],"funding":["Wellcome Trust"],"pagination":["e1002396"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3228808"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(12)"],"pubmed_abstract":["The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator of immunity that protects against invasive disease, with data suggesting a critical role for Th17 cells in mucosal clearance. By assessing CD4 T cell proliferative responses we demonstrate age-related sequestration of Th1 and Th17 CD4(+) T cells reactive to pneumococcal protein antigens within mucosal lymphoid tissue. CD25(hi) T cell depletion and utilisation of pneumococcal specific MHCII tetramers revealed the presence of antigen specific Tregs that utilised CTLA-4 and PDL-1 surface molecules to suppress these res"],"journal":["PLoS pathogens"],"pubmed_title":["Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue."],"pmcid":["PMC3228808"],"funding_grant_id":["083603/B/07/Z"],"pubmed_authors":["Heyderman RS","Kwok WW","Mitchell TJ","Pido-Lopez J","Williams NA"],"additional_accession":[]},"is_claimable":false,"name":"Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue.","description":"The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator of immunity that protects against invasive disease, with data suggesting a critical role for Th17 cells in mucosal clearance. By assessing CD4 T cell proliferative responses we demonstrate age-related sequestration of Th1 and Th17 CD4(+) T cells reactive to pneumococcal protein antigens within mucosal lymphoid tissue. CD25(hi) T cell depletion and utilisation of pneumococcal specific MHCII tetramers revealed the presence of antigen specific Tregs that utilised CTLA-4 and PDL-1 surface molecules to suppress these res","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-19T01:17:27.763Z","creation":"2019-03-27T00:46:37Z"},"accession":"S-EPMC3228808","cross_references":{"pubmed":["22144893"],"doi":["10.1371/journal.ppat.1002396"]}}