{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bortolato M"],"funding":["NICHD NIH HHS","NIMH NIH HHS"],"pagination":["2674-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3230491"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(13)"],"pubmed_abstract":["Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). In humans and mice, total MAO-A deficiency results in high 5-HT and NE levels, as well as elevated reactive aggression. Here we report the generation of MAO-A(Neo) mice, a novel line of hypomorphic MAO-A mutants featuring the insertion of a floxed neomycin-resistance cassette in intron-12 of the Maoa gene. This construct resulted in a chimeric, non-functional variant of the Maoa-Neo transcript, with a truncated C-terminus, likely due to aberrant splicing; these deficits notwithstanding, small amounts of functional Maoa transcript were found in the brain of MAO-A(Neo) mice. In the prefrontal cortex and amygdala, MAO-A(Neo) mice showed low, yet detectable, MAO"],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice."],"pmcid":["PMC3230491"],"funding_grant_id":["R03 MH087794","R01MH39085","R37 MH039085","R03MH087794","R21 HD070611","R37MH39085","R01 MH039085","R21HD070611"],"pubmed_authors":["Scott AL","Bortolato M","Shih JC","Wellman CL","Chen K","Godar SC","Farrell MR","Chen G","Rebrin I","Wu W"],"additional_accession":[]},"is_claimable":false,"name":"Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice.","description":"Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). In humans and mice, total MAO-A deficiency results in high 5-HT and NE levels, as well as elevated reactive aggression. Here we report the generation of MAO-A(Neo) mice, a novel line of hypomorphic MAO-A mutants featuring the insertion of a floxed neomycin-resistance cassette in intron-12 of the Maoa gene. This construct resulted in a chimeric, non-functional variant of the Maoa-Neo transcript, with a truncated C-terminus, likely due to aberrant splicing; these deficits notwithstanding, small amounts of functional Maoa transcript were found in the brain of MAO-A(Neo) mice. In the prefrontal cortex and amygdala, MAO-A(Neo) mice showed low, yet detectable, MAO","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-07-09T03:04:50.874Z","creation":"2025-07-09T03:04:50.874Z"},"accession":"S-EPMC3230491","cross_references":{"pubmed":["21832987"],"doi":["10.1038/npp.2011.157"]}}