biostudies-literatureUnknown55(12)Kim WYA recent in vitro study showed that the three compounds of antiviral drugs with different mechanisms of action (amantadine, ribavirin, and oseltamivir) could result in synergistic antiviral activity against influenza virus. However, no clinical studies have evaluated the efficacy and safety of combination antiviral therapy in patients with severe influenza illness. A total of 245 adult patients who were critically ill with confirmed pandemic influenza A/H1N1 2009 (pH1N1) virus infection and were admitted to one of the intensive care units of 28 hospitals in Korea were reviewed. Patients who required ventilator support and received either triple-combination antiviral drug (TCAD) therapy or oseltamivir monotherapy were analyzed. A total of 127 patients were included in our analysis. Among thAntimicrobial agents and chemotherapy5703-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3232815biostudies-literatureTriple-combination antiviral drug for pandemic H1N1 influenza virus infection in critically ill patients on mechanical ventilation.PMC3232815Won Huh JYoung Suh GLee HBSuk Park MKim WYKoh YKorean Society of Critical Care Medicine H1N1 CollaborativeKim KUHuh JWRyu YJSoo Han MKim SHKim SCYoung Lim CCho JHHan MSJoo Lee YLee HKKim MJKim YSLee MGSeong Kim YBum Park YSook Kim YHong SBChoi HSYoung Choi EJeon KKim HRSuh GYAhn JJChon GRLim CMChoi SHKwak SHCheol Kim HChoi WIKo YGLim JYeol Kim JYun SCGwan Ko YLee KHHo Lee KfalseTriple-combination antiviral drug for pandemic H1N1 influenza virus infection in critically ill patients on mechanical ventilation.A recent in vitro study showed that the three compounds of antiviral drugs with different mechanisms of action (amantadine, ribavirin, and oseltamivir) could result in synergistic antiviral activity against influenza virus. However, no clinical studies have evaluated the efficacy and safety of combination antiviral therapy in patients with severe influenza illness. A total of 245 adult patients who were critically ill with confirmed pandemic influenza A/H1N1 2009 (pH1N1) virus infection and were admitted to one of the intensive care units of 28 hospitals in Korea were reviewed. Patients who required ventilator support and received either triple-combination antiviral drug (TCAD) therapy or oseltamivir monotherapy were analyzed. A total of 127 patients were included in our analysis. Among th2011-01-01T00:00:00Z2011 Dec2025-04-04T21:13:35.473Z2019-03-27T00:46:45ZS-EPMC32328152196837110.1128/AAC.05529-1110.1128/aac.05529-11