{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petrova OE"],"funding":["NHLBI NIH HHS"],"pagination":["6614-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3232883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["193(23)"],"pubmed_abstract":["The interaction of Pseudomonas aeruginosa with surfaces has been described as a two-stage process requiring distinct signaling events and the reciprocal modulation of small RNAs (sRNAs). However, little is known regarding the relationship between sRNA-modulating pathways active under planktonic or surface-associated growth conditions. Here, we demonstrate that SagS (PA2824), the cognate sensor of HptB, links sRNA-modulating activities via the Gac/HptB/Rsm system postattachment to the signal transduction network BfiSR, previously demonstrated to be required for the development of P. aeruginosa. Consistent with the role of SagS in the GacA-dependent HtpB signaling pathway, inactivation of sagS resulted in hyperattachment, an HptB-dependent increase in rsmYZ, increased Psl polysaccharide prod"],"journal":["Journal of bacteriology"],"pubmed_title":["SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation."],"pmcid":["PMC3232883"],"funding_grant_id":["2R15 HL073835-02","R15 HL073835-02","R15 HL073835"],"pubmed_authors":["Sauer K","Petrova OE"],"additional_accession":[]},"is_claimable":false,"name":"SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation.","description":"The interaction of Pseudomonas aeruginosa with surfaces has been described as a two-stage process requiring distinct signaling events and the reciprocal modulation of small RNAs (sRNAs). However, little is known regarding the relationship between sRNA-modulating pathways active under planktonic or surface-associated growth conditions. Here, we demonstrate that SagS (PA2824), the cognate sensor of HptB, links sRNA-modulating activities via the Gac/HptB/Rsm system postattachment to the signal transduction network BfiSR, previously demonstrated to be required for the development of P. aeruginosa. Consistent with the role of SagS in the GacA-dependent HtpB signaling pathway, inactivation of sagS resulted in hyperattachment, an HptB-dependent increase in rsmYZ, increased Psl polysaccharide prod","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-04T21:13:38.454Z","creation":"2019-03-27T00:46:46Z"},"accession":"S-EPMC3232883","cross_references":{"pubmed":["21949078"],"doi":["10.1128/jb.00305-11","10.1128/JB.00305-11"]}}