{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["77(24)"],"submitter":["Thomas F"],"pubmed_abstract":["In spite of the significant impact of biomethylation on the mobility and toxicity of metals and metalloids in the environment, little is known about the biological formation of these methylated metal(loid) compounds. While element-specific methyltransferases have been isolated for arsenic, the striking versatility of methanoarchaea to methylate numerous metal(loid)s, including rare elements like bismuth, is still not understood. Here, we demonstrate that the same metal(loid)s (arsenic, selenium, antimony, tellurium, and bismuth) that are methylated by Methanosarcina mazei in vivo are also methylated by in vitro assays with purified recombinant MtaA, a methyltransferase catalyzing the methyl transfer from methylcobalamin [CH₃Cob(III)] to 2-mercaptoethanesulfonic acid (CoM) in methylotrophic"],"journal":["Applied and environmental microbiology"],"pagination":["8669-75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3233109"],"repository":["biostudies-literature"],"pubmed_title":["Connection between multimetal(loid) methylation in methanoarchaea and central intermediates of methanogenesis."],"pmcid":["PMC3233109"],"pubmed_authors":["Wuerfel O","Thomas F","Diaz-Bone RA","Huber B","Weidenbach K","Hensel R","Schmitz RA"],"additional_accession":[]},"is_claimable":false,"name":"Connection between multimetal(loid) methylation in methanoarchaea and central intermediates of methanogenesis.","description":"In spite of the significant impact of biomethylation on the mobility and toxicity of metals and metalloids in the environment, little is known about the biological formation of these methylated metal(loid) compounds. While element-specific methyltransferases have been isolated for arsenic, the striking versatility of methanoarchaea to methylate numerous metal(loid)s, including rare elements like bismuth, is still not understood. Here, we demonstrate that the same metal(loid)s (arsenic, selenium, antimony, tellurium, and bismuth) that are methylated by Methanosarcina mazei in vivo are also methylated by in vitro assays with purified recombinant MtaA, a methyltransferase catalyzing the methyl transfer from methylcobalamin [CH₃Cob(III)] to 2-mercaptoethanesulfonic acid (CoM) in methylotrophic","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2026-04-15T13:20:39.355Z","creation":"2026-04-07T13:56:00.07Z"},"accession":"S-EPMC3233109","cross_references":{"pubmed":["22003009"],"doi":["10.1128/aem.06406-11","10.1128/AEM.06406-11"]}}