{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Come CE"],"funding":["NHLBI NIH HHS"],"pagination":["109-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3233645"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["106(1)"],"pubmed_abstract":["<h4>Background</h4>In COPD patients, hyperinflation impairs cardiac function. We examined whether lung deflation improves oxygen pulse, a surrogate marker of stroke volume.<h4>Methods</h4>In 129 NETT patients with cardiopulmonary exercise testing (CPET) and arterial blood gases (ABG substudy), hyperinflation was assessed with residual volume to total lung capacity ratio (RV/TLC), and cardiac function with oxygen pulse (O(2) pulse=VO(2)/HR) at baseline and 6 months. Medical and surgical patients were divided into \"deflators\" and \"non-deflators\" based on change in RV/TLC from baseline (∆RV/TLC). We defined deflation as the ∆RV/TLC experienced by 75% of surgical patients. We examined changes in O(2) pulse at peak and similar (iso-work) exercise. Findings were validated in 718 patients who und"],"journal":["Respiratory medicine"],"pubmed_title":["Lung deflation and oxygen pulse in COPD: results from the NETT randomized trial."],"pmcid":["PMC3233645"],"funding_grant_id":["T32 HL007633","N01 HR076101","N01 HR076102","K23HL089353-01A1","N01 HR076116","N01 HR076114","N01 HR076115","N01 HR076118","N01 HR076119","N01 HR076112","N01 HR076113","N01 HR076110","N01 HR076111","K25 HL104085","K23 HL089353","U10 HL074428","T32HL007633-25","N01 HR076105","N01 HR076106","N01 HR076103","U10HL074428-05","N01 HR076104","N01 HR076109","N01 HR076107","N01 HR076108"],"pubmed_authors":["Young C","Hooper S","Sexton J","Boitano L","Moskowitz I","Mullan B","Durr T","Ayres G","Cordova F","Rodarte J","Benedict B","McAdams H","Vilotijevic D","Dweik R","Lawlor B","Gerber R","Roessler L","NETT Research Group","Waldhausen JA","Howe J","Russell R","Gilmartin M","Kazerooni E","Russell W","White K","Boiselle P","Newell J","Lipson D","Qi S","Reardon M","Stanford 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SM","Pfeffer J","Kwak C","Campbell K","Nguyen C","Brown M","Kopp T","Cherniack R","Fuller J"],"additional_accession":[]},"is_claimable":false,"name":"Lung deflation and oxygen pulse in COPD: results from the NETT randomized trial.","description":"<h4>Background</h4>In COPD patients, hyperinflation impairs cardiac function. We examined whether lung deflation improves oxygen pulse, a surrogate marker of stroke volume.<h4>Methods</h4>In 129 NETT patients with cardiopulmonary exercise testing (CPET) and arterial blood gases (ABG substudy), hyperinflation was assessed with residual volume to total lung capacity ratio (RV/TLC), and cardiac function with oxygen pulse (O(2) pulse=VO(2)/HR) at baseline and 6 months. Medical and surgical patients were divided into \"deflators\" and \"non-deflators\" based on change in RV/TLC from baseline (∆RV/TLC). We defined deflation as the ∆RV/TLC experienced by 75% of surgical patients. We examined changes in O(2) pulse at peak and similar (iso-work) exercise. Findings were validated in 718 patients who und","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2026-04-18T09:15:57.128Z","creation":"2019-03-27T00:46:50Z"},"accession":"S-EPMC3233645","cross_references":{"pubmed":["21843930"],"doi":["10.1016/j.rmed.2011.07.012"]}}