{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(12)"],"submitter":["Konopova B"],"pubmed_abstract":["Insect larvae metamorphose to winged and reproductive adults either directly (hemimetaboly) or through an intermediary pupal stage (holometaboly). In either case juvenile hormone (JH) prevents metamorphosis until a larva has attained an appropriate phase of development. In holometabolous insects, JH acts through its putative receptor Methoprene-tolerant (Met) to regulate Krüppel-homolog 1 (Kr-h1) and Broad-Complex (BR-C) genes. While Met and Kr-h1 prevent precocious metamorphosis in pre-final larval instars, BR-C specifies the pupal stage. How JH signaling operates in hemimetabolous insects is poorly understood. Here, we compare the function of Met, Kr-h1 and BR-C genes in the two types of insects. Using systemic RNAi in the hemimetabolous true bug, Pyrrhocoris apterus, we show that Met co"],"journal":["PloS one"],"pagination":["e28728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3234286"],"repository":["biostudies-literature"],"pubmed_title":["Common and distinct roles of juvenile hormone signaling genes in metamorphosis of holometabolous and hemimetabolous insects."],"pmcid":["PMC3234286"],"pubmed_authors":["Jindra M","Konopova B","Smykal V"],"additional_accession":[]},"is_claimable":false,"name":"Common and distinct roles of juvenile hormone signaling genes in metamorphosis of holometabolous and hemimetabolous insects.","description":"Insect larvae metamorphose to winged and reproductive adults either directly (hemimetaboly) or through an intermediary pupal stage (holometaboly). In either case juvenile hormone (JH) prevents metamorphosis until a larva has attained an appropriate phase of development. In holometabolous insects, JH acts through its putative receptor Methoprene-tolerant (Met) to regulate Krüppel-homolog 1 (Kr-h1) and Broad-Complex (BR-C) genes. While Met and Kr-h1 prevent precocious metamorphosis in pre-final larval instars, BR-C specifies the pupal stage. How JH signaling operates in hemimetabolous insects is poorly understood. Here, we compare the function of Met, Kr-h1 and BR-C genes in the two types of insects. Using systemic RNAi in the hemimetabolous true bug, Pyrrhocoris apterus, we show that Met co","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011","modification":"2026-05-04T08:01:04.1Z","creation":"2019-03-26T23:18:17Z"},"accession":"S-EPMC3234286","cross_references":{"pubmed":["22174880"],"doi":["10.1371/journal.pone.0028728"]}}