biostudies-literatureKishore SNEI NIH HHSNIA NIH HHS201-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC3236797biostudies-literatureUnknown22(1)We presented naturalistic combinations of virtual self-movement stimuli while recording neuronal activity in monkey cerebral cortex. Monkeys used a joystick to drive to a straight ahead heading direction guided by either object motion or optic flow. The selected cue dominates neuronal responses, often mimicking responses evoked when that stimulus is presented alone. In some neurons, driving strategy creates selective response additivities. In others, it creates vulnerabilities to the disruptive effects of independently moving objects. Such cue interactions may be related to the disruptive effects of independently moving objects in Alzheimer's disease patients with navigational deficits.Cerebral cortex (New York, N.Y. : 1991)Driving strategy alters neuronal responses to self-movement: cortical mechanisms of distracted driving.PMC3236797R01 EY010287T32EY07125R01 EY022062R01-EY10287P30EY01319R01 AG017596Duffy CJPage WKSato NKishore SHornick NfalseDriving strategy alters neuronal responses to self-movement: cortical mechanisms of distracted driving.We presented naturalistic combinations of virtual self-movement stimuli while recording neuronal activity in monkey cerebral cortex. Monkeys used a joystick to drive to a straight ahead heading direction guided by either object motion or optic flow. The selected cue dominates neuronal responses, often mimicking responses evoked when that stimulus is presented alone. In some neurons, driving strategy creates selective response additivities. In others, it creates vulnerabilities to the disruptive effects of independently moving objects. Such cue interactions may be related to the disruptive effects of independently moving objects in Alzheimer's disease patients with navigational deficits.2012-01-01T00:00:00Z2012 Jan2024-11-09T14:28:08.033Z2019-03-27T00:46:59ZS-EPMC32367972165328710.1093/cercor/bhr115