{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(11)"],"submitter":["Pilgrim CH"],"pubmed_abstract":["<h4>Introduction</h4>Chemotherapy-induced hepatic injuries (CIHI) are an increasing problem facing hepatic surgeons. It may be possible to predict the risk of developing CIHI by analysis of genes involved in the metabolism of chemotherapeutics, previously established as associated with other forms of toxicity.<h4>Methods</h4>Quantitative reverse transcriptase-polymerase chain reaction methodology (q-RT-PCR) was employed to quantify mRNA expression of nucleotide excision repair genes ERCC1 and ERCC2, relevant in the neutralization of damage induced by oxaliplatin, and genes encoding enzymes relevant to 5-flurouracil metabolism, [thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD)] in 233 hepatic resection samples. mRNA expression was correlated "],"journal":["HPB : the official journal of the International Hepato Pancreato Biliary Association"],"pagination":["811-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3238016"],"repository":["biostudies-literature"],"pubmed_title":["mRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury."],"pmcid":["PMC3238016"],"pubmed_authors":["Evans PM","Banting S","Smith M","Pilgrim CH","Link E","Phillips WA","Murray W","Thomson BN","Michael M","Brettingham-Moore K","Usatoff V","Pham A"],"additional_accession":[]},"is_claimable":false,"name":"mRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury.","description":"<h4>Introduction</h4>Chemotherapy-induced hepatic injuries (CIHI) are an increasing problem facing hepatic surgeons. It may be possible to predict the risk of developing CIHI by analysis of genes involved in the metabolism of chemotherapeutics, previously established as associated with other forms of toxicity.<h4>Methods</h4>Quantitative reverse transcriptase-polymerase chain reaction methodology (q-RT-PCR) was employed to quantify mRNA expression of nucleotide excision repair genes ERCC1 and ERCC2, relevant in the neutralization of damage induced by oxaliplatin, and genes encoding enzymes relevant to 5-flurouracil metabolism, [thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD)] in 233 hepatic resection samples. mRNA expression was correlated ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2026-04-13T13:40:42.473Z","creation":"2026-04-07T13:29:59.982Z"},"accession":"S-EPMC3238016","cross_references":{"pubmed":["21999595"],"doi":["10.1111/j.1477-2574.2011.00365.x"]}}