{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Teruel M"],"pubmed_abstract":["Introduction
Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.Methods
A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a p"],"journal":["Arthritis research & therapy"],"pagination":["R116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3239354"],"repository":["biostudies-literature"],"pubmed_title":["Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients."],"pmcid":["PMC3239354"],"pubmed_authors":["Bottini N","Miranda-Filloy JA","Blanco R","Gonzalez-Juanatey C","Gomez-Vaquero C","Teruel M","Rodriguez-Rodriguez L","Fernandez-Gutierrez B","Lopez-Mejias R","Gonzalez-Alvaro I","Llorca J","Gonzalez-Gay MA","Balsa A","Pascual-Salcedo D","Martin J","Martin JE","Ortiz AM"],"additional_accession":[]},"is_claimable":false,"name":"Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients.","description":"Introduction
Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell. The aim of this study was to determine the contribution of ACP1 polymorphisms to susceptibility to rheumatoid arthritis (RA), as well as the potential contribution of these polymorphisms to the increased risk of cardiovascular disease (CV) observed in RA patients.Methods
A set of 1,603 Spanish RA patients and 1,877 healthy controls were included in the study. Information related to the presence/absence of CV events was obtained from 1,284 of these participants. All individuals were genotyped for four ACP1 single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247, and rs3828329, using a p","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jul","modification":"2026-04-07T13:53:24.944Z","creation":"2019-03-27T00:47:03Z"},"accession":"S-EPMC3239354","cross_references":{"pubmed":["21767392"],"doi":["10.1186/ar3401"]}}