{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu LG"],"funding":["NIAID NIH HHS"],"pagination":["248-58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3244560"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["188(1)"],"pubmed_abstract":["B cells play a critical role in the initialization and development of the systemic lupus erythematosus that is dependent on the expression of the endosomal ssRNA receptor TLR7. Previous studies have established that B cell expression of TLR7 is controlled by the type I IFN secreted by plasmacytoid dendritic cells. In this article, we report that VISA, also known as MAVS, IPS-1, and CardIf, essential for RIG-I/MDA5-mediated signaling following sensing of cytosolic RNA, regulate B cell expression of TLR7 and CD23. We found that B cells from a VISA(-/-) mouse express reduced TLR7 but normal basal levels of type I IFN. We also show that although IFN-β and TLR7 agonists synergize to promote TLR7 expression in VISA(-/-) B cells, they do not fully complement the defect seen in VISA(-/-) cells. Ce"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["VISA is required for B cell expression of TLR7."],"pmcid":["PMC3244560"],"funding_grant_id":["P01 AI022295","P01AI022295022","P01 AI022295-22","R01 AI062739-05S1","R01 AI062739-05S2","R01 AI062739-05","R01 AI062739","R01AI062739-05","R01AI062739-05S2","R01AI062739-05S1"],"pubmed_authors":["Zhang BC","Xu LG","Akerlund LJ","Shu HB","Jin L","Cambier JC"],"additional_accession":[]},"is_claimable":false,"name":"VISA is required for B cell expression of TLR7.","description":"B cells play a critical role in the initialization and development of the systemic lupus erythematosus that is dependent on the expression of the endosomal ssRNA receptor TLR7. Previous studies have established that B cell expression of TLR7 is controlled by the type I IFN secreted by plasmacytoid dendritic cells. In this article, we report that VISA, also known as MAVS, IPS-1, and CardIf, essential for RIG-I/MDA5-mediated signaling following sensing of cytosolic RNA, regulate B cell expression of TLR7 and CD23. We found that B cells from a VISA(-/-) mouse express reduced TLR7 but normal basal levels of type I IFN. We also show that although IFN-β and TLR7 agonists synergize to promote TLR7 expression in VISA(-/-) B cells, they do not fully complement the defect seen in VISA(-/-) cells. Ce","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jan","modification":"2025-04-18T17:24:39.376Z","creation":"2019-03-26T23:42:55Z"},"accession":"S-EPMC3244560","cross_references":{"pubmed":["22105994"],"doi":["10.4049/jimmunol.1100918"]}}