{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dufour C"],"funding":["Association pour la Recherche sur le Cancer","Coordenação de Aperfeiçoamento do Pessoal de Nivel Superior-Comité Français d'Évaluation de la Coopération Universitaire et Scientifique avec le Brésil","Institut National de la Santé et de la Recherche Médicale","Fondation pour la Recherche Médicale","Association pour la Recherche dans les Tumeurs Cérébrales"],"pagination":["2373-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3245240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(10)"],"pubmed_abstract":["Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these c"],"journal":["Stem cells (Dayton, Ohio)"],"pubmed_title":["Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation."],"pmcid":["PMC3245240"],"funding_grant_id":["3500","3972","3131"],"pubmed_authors":["Daudigeos E","Sharif A","Dias-Morais A","Lazar V","Cadusseau J","Varlet P","Dufour C","de Faria GP","Leonard N","Dantas-Barbosa C","Grill J","Surena AL","Auger N","Chneiweiss H","Dessen P","Vassal G","Prevot V","Junier MP"],"additional_accession":[]},"is_claimable":false,"name":"Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation.","description":"Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these c","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Oct","modification":"2026-05-01T02:04:08.941Z","creation":"2026-04-07T16:34:10.972Z"},"accession":"S-EPMC3245240","cross_references":{"pubmed":["19544474"],"doi":["10.1002/stem.155"]}}