biostudies-literatureDufour CAssociation pour la Recherche sur le CancerCoordenação de Aperfeiçoamento do Pessoal de Nivel Superior-Comité Français d'Évaluation de la Coopération Universitaire et Scientifique avec le BrésilInstitut National de la Santé et de la Recherche MédicaleFondation pour la Recherche MédicaleAssociation pour la Recherche dans les Tumeurs Cérébrales2373-82https://www.ebi.ac.uk/biostudies/studies/S-EPMC3245240biostudies-literatureUnknown27(10)Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these cStem cells (Dayton, Ohio)Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation.PMC3245240350039723131Daudigeos ESharif ADias-Morais ALazar VCadusseau JVarlet PDufour Cde Faria GPLeonard NDantas-Barbosa CGrill JSurena ALAuger NChneiweiss HDessen PVassal GPrevot VJunier MPfalseAstrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation.Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these c2009-01-01T00:00:00Z2009 Oct2026-05-01T02:04:08.941Z2026-04-07T16:34:10.972ZS-EPMC32452401954447410.1002/stem.155