biostudies-literatureNovikov YNIGMS NIH HHS1913-1915https://www.ebi.ac.uk/biostudies/studies/S-EPMC3245685biostudies-literatureUnknown52(16)4-Phospho-D-erythronate is an intermediate in synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-D-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-D-erythronate from the inexpensive precursor D-erythronolactone in 5 steps with a preparatively useful yield of 22%.Tetrahedron lettersA Simple Route for Synthesis of 4-Phospho-D-Erythronate.PMC3245685R01 GM083285-03R01 GM083285Copley SDEaton BENovikov YfalseA Simple Route for Synthesis of 4-Phospho-D-Erythronate.4-Phospho-D-erythronate is an intermediate in synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-D-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-D-erythronate from the inexpensive precursor D-erythronolactone in 5 steps with a preparatively useful yield of 22%.2011-01-01T00:00:00Z2011 Apr2025-04-22T04:48:31.75Z2019-03-27T00:47:20ZS-EPMC32456852220098010.1016/j.tetlet.2011.02.045